Chlorotonil A
Chlorotonil A is an orally active Antibacterial and antimalarial agent. Chlorotonil A is isolated from Sorangium cellulosum. Chlorotonil A inhibits the germination of Clostridioides difficile spores into vegetative cells. Chlorotonil A exhibits antibacterial activity against Gram-positive bacteria and gametocytocidal activity against mature Plasmodium falciparum gametocytes. Chlorotonil A reduces parasitemia in the murine Plasmodium berghei model and prevents recurrent C. difficile infection in mice. Chlorotonil A can be used for research on malaria and Clostridioides difficile infection.
For research use only. We do not sell to patients.
- CAS No.: 1009813-26-6
- Formula: C26H32Cl2O4
- Molecular Weight:479.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[3]|
Microbial Metabolite |
In Vitro
Chlorotonil A (0.1 μg/mL and above) inhibits the outgrowth of C. difficile VPI10463 spores into vegetative cells, with complete inhibition observed at concentrations of 0.4 μg/mL and above[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Chlorotonil A (40 mg/kg; p.o.) maintains colonization resistance against C. difficile in mice, preventing colonization and disease[3].
Chlorotonil A (2 × 5 mg/kg; intravenous injection) reduces the bacterial burden of Staphylococcus aureus by approximately 4 log units in a mouse thigh infection model[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6N SPF mice (female and male, 6-30 weeks old)[3]
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Dosage:40 mg/kg
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Administration:p.o.; on days 1 and 2; or on day −1 as pre-treatment
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Result:Achieved a final survival rate of 66.6% (6/9 mice).
Cleared C. difficile completely by day 7 in 83.3% of surviving mice (5/6).
Reduced amounts of toxins approximately 100-fold compared with vancomycin-treated mice at day 5.
Resulted in significantly slower onset of disease and minor severity compared with control in the pre-treatment experiment.
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Animal Model:C57BL/6N SPF mice (female and male, 6-30 weeks old)[3]
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Dosage:40 mg/kg
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Administration:p.o.; single dose
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Result:Did not lead to phenotypic disease.
No vegetative cells or spores were detected in ChA-treated mice.
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Animal Model:Mice[4]
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Dosage:2 × 5 mg/kg
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Administration:i.v.
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Result:Reduced bacterial burden in the thigh by approximately 4 log.
Chemical Information
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CAS No. 1009813-26-6
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Molecular Weight 479.44
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Formula C26H32Cl2O4
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SMILES
O=C1C(Cl)(Cl)C([C@H](C)C(O[C@@H](C)/C=C/C=C\[C@@H](C)[C@@]2([H])[C@]1([H])[C@]3([H])[C@H](C)C=C(C)C[C@@]3([H])C=C2)=O)=O
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Structure Classification
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Initial Source
Sorangium cellulosum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chlorotonil A Related Classifications
HY-187854 Related Classifications
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Keywords
- Chlorotonil A
- 1009813-26-6
- Antibiotic
- Endogenous Metabolite
- Bacterial
- Parasite
- Sorangium cellulosum Soce1525
- HepG2 cells
- Plasmodium falciparum
- spore outgrowth
- Staphylococcus aureus
- colonization resistance
- B. subtilis 168 pCHlux101-PiseA
- Plasmodium berghei
- Streptococcus pneumoniae
- Clostridioides difficile
- Inhibitor
- inhibitor
- inhibit