Cholesteryl linoleate-d11
Cholesteryl linoleate-d11 is the d11-labeled Cholesteryl linoleate (HY-W010697). Cholesteryl linoleate is a cholesteryl ester with antibacterial activity that is present in low-density lipoprotein (LDL) particles, human nasal fluid, and respiratory epithelial secretions. Cholesteryl linoleate is oxidized by 12/15-lipoxygenase in macrophages and participates in selective uptake and efflux via LDL receptor-related protein. Cholesteryl linoleate does not induce endothelial adhesion molecule expression, nor does it induce monocyte binding to endothelial cells. Cholesteryl linoleate liposomal formulations inhibit the growth of multiple bacteria at physiological nasal fluid concentrations and act synergistically with antimicrobial peptides. Cholesteryl linoleate is useful for research related to atherosclerosis and bacterial infections.
For research use only. We do not sell to patients.
- Formula: C45H65D11O2
- Molecular Weight:660.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Human Endogenous Metabolite |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 604-33-1
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Molecular Weight 660.15
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Formula C45H65D11O2
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SMILES
C[C@@]12C(C[C@H](CC1)OC(CCCCCCC/C=C\C/C=C\C([2H])(C([2H])(C([2H])(C([2H])([2H])C([2H])([2H])[2H])[2H])[2H])[2H])=O)=CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@]4([H])[C@H](C)CCCC(C)C)[H])C)[H])[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Huber J, et al. Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway. Arteriosclerosis, thrombosis, and vascular biology. 2002 Apr 01;22(4):581-6. [Content Brief]
[3]. Do TQ, et al. Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. J Immunol. 2008 Sep 15;181(6):4177-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cholesteryl linoleate-d11 Related Classifications
HY-W010697S Related Classifications
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Keywords
- Cholesteryl linoleate-d11
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Bacterial
- human umbilical vein endothelial cells
- 12/15-lipoxygenase
- U937 cells
- macrophages
- respiratory epithelial secretions
- Pseudomonas aeruginosa
- atherosclerosis
- low-density lipoprotein particles
- LDL receptor-related protein
- human nasal fluid
- Inhibitor
- inhibitor
- inhibit