Cat. No.: HY-B1337S1

Choline-d₉ chloride

Name: Choline-d9 chloride
Brand: MedChemExpress
SKU: HY-B1337S1
Price: 95.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Choline-d₉ chloride is the d₉-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma.

For research use only. We do not sell to patients.

Purity : 99.98%
CAS No.: 61037-86-3
Formula: C₅H₅D₉ClNO
Molecular Weight:148.68

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Choline-d₉ chloride Chemical Structure

CAS No.: 61037-86-3

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Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
- Application
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Histamine Receptor Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 61037-86-3
Unlabeled CAS 67-48-1
Appearance Solid
Molecular Weight 148.68
Formula C₅H₅D₉ClNO
Color Off-white to light yellow
SMILES

[2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (3)

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Anal Chem

In Situ Derivatization Combined with DESI-MRM-MS/MS for Spatial Mapping Intratissue Amine-Containing Metabolites, Trimethylamine as a Case. [Abstract]

2026 Feb 7. PMID: 41653191
Clin Chim Acta

SAH and SAM/SAH ratio associate with acute kidney injury in critically ill patients: A case-control study. [Abstract]

2024 Jan 15:553:117726. PMID: 38110027
J Chromatogr B Analyt Technol Biomed Life Sci

Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS. [Abstract]

2024 Aug 1:1243:124210. PMID: 38936270

Solvent & Solubility

In Vitro:

DMSO : ≥ 140 mg/mL (941.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (672.59 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.7259 mL

33.6293 mL

67.2585 mL

5 mM

1.3452 mL

6.7259 mL

13.4517 mL

10 mM

0.6726 mL

3.3629 mL

6.7259 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. ARMITAGE AK, et al. Thioxanthines with potent brochodilator and coronary dilator properties. Br J Pharmacol Chemother. 1961 Feb;16(1):59-76.

[2]. Rhind GB, et al. Sustained release choline theophyllinate in nocturnal asthma. British medical journal (Clinical research ed.). 1985 Dec 07;291(6509):1605-7.

[3]. Hibberd SG, et al. Acute and chronic pharmacokinetics of asymmetrical doses of slow release choline theophyllinate in asthma. British journal of clinical pharmacology. 1986 Sep;22(3):337-41.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	6.7259 mL	33.6293 mL	67.2585 mL	168.1464 mL
	5 mM	1.3452 mL	6.7259 mL	13.4517 mL	33.6293 mL
	10 mM	0.6726 mL	3.3629 mL	6.7259 mL	16.8146 mL
	15 mM	0.4484 mL	2.2420 mL	4.4839 mL	11.2098 mL
	20 mM	0.3363 mL	1.6815 mL	3.3629 mL	8.4073 mL
	25 mM	0.2690 mL	1.3452 mL	2.6903 mL	6.7259 mL
	30 mM	0.2242 mL	1.1210 mL	2.2420 mL	5.6049 mL
	40 mM	0.1681 mL	0.8407 mL	1.6815 mL	4.2037 mL
	50 mM	0.1345 mL	0.6726 mL	1.3452 mL	3.3629 mL
	60 mM	0.1121 mL	0.5605 mL	1.1210 mL	2.8024 mL
	80 mM	0.0841 mL	0.4204 mL	0.8407 mL	2.1018 mL
	100 mM	0.0673 mL	0.3363 mL	0.6726 mL	1.6815 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Keywords

Choline-d₉ chloride

3 Cited Publications

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Choline-d₉ chloride

Publications Citing Use of MedChemExpress (MCE) Choline-d₉ chloride

All Histamine Receptor Isoforms