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Cat. No.: HY-N14037

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Chondramide C

Chondramide C has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.

For research use only. We do not sell to patients.

CAS No.: 172430-62-5
Formula: C₃₅H₄₄N₄O₆
Molecular Weight:616.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Chondramide C Chemical Structure

CAS No.: 172430-62-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Chondramide C has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC50	23 nM	Cytotoxicity against human MCF-7 cells by cell viability assay. Cytotoxicity against human MCF-7 cells by cell viability assay.	22475347
HT-29	IC50	21 nM	Cytotoxicity against human HT-29 cells by cell viability assay. Cytotoxicity against human HT-29 cells by cell viability assay.	22475347
MCF7	IC50	0.023 μM	Cytotoxicity of natural Chondramide C against human MCF-7 breast cancer cells. Cytotoxicity of natural Chondramide C against human MCF-7 breast cancer cells.	20148556
HT-29	IC50	0.021 μM	Cytotoxicity of natural Chondramide C against human HT-29 colorectal cancer cells. Cytotoxicity of natural Chondramide C against human HT-29 colorectal cancer cells.	20148556
MCF7	IC50	0.083 μM	Cytotoxicity of Synthetic Chondramide C against human MCF-7 breast cancer cells. Cytotoxicity of Synthetic Chondramide C against human MCF-7 breast cancer cells.	20148556
HT-29	IC50	0.031 μM	Cytotoxicity of Synthetic Chondramide C against human HT-29 colorectal cancer cells. Cytotoxicity of Synthetic Chondramide C against human HT-29 colorectal cancer cells.	20148556

In Vitro

Anti-cancerOthers

Anti-cancer

Chondramide C is cytotoxic to MCF-7 and HT-29 cells, with IC₅₀ values of 0.023 and 0.021 μM for the natural product and 0.083 and 0.031 μM for the synthetic product, respectively^[1]^[3].

Others

Chondramide C (10 mM; 6 h) reduces actin filaments in HeLa cells^[2].
Chondramide C (compound 3c) (24 h) disrupts actin organization in BSC-1 cells, leading to loss of stress fibers and formation of perinuclear actin aggregates^[3].
Chondramide C can serve as an intermediate for the synthesis of derivatives with anticancer activity^[4].
Chondramide C shows strong binding affinity to the spike proteins of SARS-CoV-2 wild-type, N501Y, E484K, and D614G-I472V variants in molecular docking simulations, and can bind to key amino acid sites of the spike protein through molecular interactions such as hydrogen bonds and π-π stacking^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 172430-62-5
Molecular Weight 616.75
Formula C₃₅H₄₄N₄O₆
SMILES

O=C(C[C@H](C1=CC=C(O)C=C1)NC([C@@H](CC2=CNC3=C2C=CC=C3)N4C)=O)O[C@H](C)[C@H](C)/C=C(C)\C[C@H](C)C(N[C@@H](C)C4=O)=O
Structure Classification
- Others
Initial Source
- Microorganism
Myxobacterium Chondromyces crocatus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ulrike Eggert, et al. Chondramide C: synthesis, configurational assignment, and structure-activity relationship studies. Angew Chem Int Ed Engl. 2008;47(34):6478-82. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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