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Cat. No.: HY-N21712

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Cilinaphthalide A

Cilinaphthalide A is an arylnaphthalene lignan lactone that exhibits cytotoxic activity against bladder cancer and cervical cancer cell lines and possesses antibacterial activity against Escherichia coli. Cilinaphthalide A can be used for research on bladder cancer and cervical cancer.

For research use only. We do not sell to patients.

CAS No.: 238423-03-5
Formula: C₂₂H₂₀O₇
Molecular Weight:396.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cilinaphthalide A Chemical Structure

CAS No.: 238423-03-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
T-24	ED₅₀	1.3 μg/mL	Cytotoxicity against human T-24 cervical carcinoma cells. Cytotoxicity against human T-24 cervical carcinoma cells.	42152709
Ca-Ski	ED₅₀	3 μg/mL	Cytotoxicity against human CaSki cervical carcinoma cells. Cytotoxicity against human CaSki cervical carcinoma cells.	42152709
HT-3	ED₅₀	0.3 μg/mL	Cytotoxicity against human HT-3 cervical carcinoma cells. Cytotoxicity against human HT-3 cervical carcinoma cells.	42152709
HT-3	ED₅₀	2.6 μg/mL	Cytotoxicity against human HT-3 cervical carcinoma cells. Cytotoxicity against human HT-3 cervical carcinoma cells.	42152709
SiHa	ED₅₀	6.4 μg/mL	Cytotoxicity against human cervical carcinoma SiHa cells assessed as reduction in cell viability incubated for 6 days by MTT assay. Cytotoxicity against human cervical carcinoma SiHa cells assessed as reduction in cell viability incubated for 6 days by MTT assay.	10425143
PLC-PRF-5	ED₅₀	12.0 μg/mL	Cytotoxicity against human hepatoma PLC/PRF/5 cells assessed as reduction in cell viability incubated for 6 days by MTT assay. Cytotoxicity against human hepatoma PLC/PRF/5 cells assessed as reduction in cell viability incubated for 6 days by MTT assay.	10425143
NIH3T3	ED₅₀	> 8.0 μg/mL	Cytotoxicity against inducible Ha-ras oncogene transformed NIH/3T3 212 cells assessed as reduction in cell viability incubated for 6 days by MTT assay. Cytotoxicity against inducible Ha-ras oncogene transformed NIH/3T3 212 cells assessed as reduction in cell viability incubated for 6 days by MTT assay.	10425143

In Vitro

Anti-cancerBacterial InfectionOthers

Anti-cancer

Cilinaphthalide A (compound 28) exhibits cytotoxic activity against the human cervical cancer cell lines T-24, CaSki, and HT-3, with ED₅₀ values of 1.3, 3, and 0.3 μg/mL, respectively^[1].
Cilinaphthalide A (6 days) exhibits low cytotoxicity against 212 cells, with an ED₅₀ greater than 8.0 µg/mL^[3].

Bacterial Infection

Cilinaphthalide A (compound 4) exhibits antibacterial activity against Escherichia coli CMCC44103, Staphylococcus aureus CMCC26001, Salmonella typhimurium CMCC80087, Shigella flexneri CMCC51335, and Salmonella paratyphi B, with the lowest MIC of 12.5 μg/mL against Escherichia coli CMCC44103^[2].
Cilinaphthalide A (compound 1) (6 days) exhibits significant in vitro cytotoxicity against T-24, CaSki, SiHa, HT-3, and PLC/PRF/5 cell lines, with the strongest activity against HT-3 cells (ED₅₀ = 0.3 µg/mL)^[3].

Others

Cilinaphthalide A (5 μg/mL) shows no cytotoxicity against HCT-8 and Bel-7402 cells at concentrations up to 5 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 238423-03-5
Molecular Weight 396.40
Formula C₂₂H₂₀O₇
SMILES

O=C1OCC=2C(OC)=C3C=C(OC)C(OC)=CC3=C(C=4C=CC(O)=C(OC)C4)C12
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Park S, et al. Arylnaphthalene lactones: structures and pharmacological potentials. Phytochemistry Reviews. 2021 Oct;20(5):1033-54.

[2]. Zhang Y, et al. Antibacterial lignans and triterpenoids from Rostellularia procumbens. Planta medica. 2007 Dec;73(15):1596-9.

[3]. Day SH, et al. Cytotoxic lignans of Justicia ciliata. Journal of natural products. 1999 Jul;62(7):1056-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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