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Cat. No.: HY-N21713

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Cilinaphthalide B

Cilinaphthalide B is an integrin αIIbβ3 inhibitor and a phthalide derivative that inhibits platelet aggregation by binding to integrin αIIbβ3 and interfering with the conformational changes required for its activation, and it exhibits cytotoxicity against cancer cell lines. Cilinaphthalide B can be used in antiplatelet and anticancer-related research.

For research use only. We do not sell to patients.

CAS No.: 102040-06-2
Formula: C₂₃H₂₂O₇
Molecular Weight:410.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cilinaphthalide B Chemical Structure

CAS No.: 102040-06-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

αIIbβ3

All Integrin Isoforms :

In Vitro

Cilinaphthalide B interacts with integrin αIIbβ3 protein with a binding free energy of −4.575 kcal/mol, forming a π-π stacking with PHE160^[1].
Cilinaphthalide B (3 min) exhibits an antiplatelet effect on human platelet-rich plasma^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 102040-06-2
Molecular Weight 410.42
Formula C₂₃H₂₂O₇
SMILES

O=C1OCC=2C(OC)=C3C=C(OC)C(OC)=CC3=C(C=4C=CC(OC)=C(OC)C4)C12
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu S, et al. A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees. Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1):999-1009.

[2]. Wu CM, et al. Antiplatelet effect and selective binding to cyclooxygenase (COX) by molecular docking analysis of flavonoids and lignans. International Journal of Molecular Sciences. 2007 Aug 22;8(8):830-41.

[3]. Day SH, et al. Cytotoxic lignans of Justicia ciliata. Journal of natural products. 1999 Jul;62(7):1056-8. [Content Brief]

[4]. Guan L, et al. In-Depth Exploration of Chemical Constituents from Justicia procumbens L. Through UHPLC-Q-Exactive Orbitrap Mass Spectrometry. Molecules. 2025 Aug 30;30(17):3554.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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