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Cat. No.: HY-189865

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CK1δ liagnd-1

CK1δ liagnd-1 is a CK1δ-binding ligand. CK1δ liagnd-1 binds to CK1δ through key kinase interactions, can serve as a ligand for PROTAC design, and exhibits antiproliferative activity against NRAS^Q61R mutant melanoma cells. CK1δ liagnd-1 can be used for research on melanoma.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₁FN₆
Molecular Weight:352.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CK1δ liagnd-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CK1δ

All Casein Kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-MEL-103	IC50	29.97 μM	Antiproliferative activity against human SK-MEL-103 cells harboring NRASQ61R assessed as viability reduction after 72 hrs incubation by CCK-8 assay. Antiproliferative activity against human SK-MEL-103 cells harboring NRASQ61R assessed as viability reduction after 72 hrs incubation by CCK-8 assay.	acs.jmedchem.6c01152
SK-MEL-2	IC50	11.73 μM	Antiproliferative activity against human SK-MEL-2 cells harboring NRASQ61R assessed as viability reduction after 72 hrs incubation by CCK-8 assay. Antiproliferative activity against human SK-MEL-2 cells harboring NRASQ61R assessed as viability reduction after 72 hrs incubation by CCK-8 assay.	acs.jmedchem.6c01152

In Vitro

Anti-cancerOthers

Anti-cancer

CK1δ ligand-1 (compound 7) (72 h) inhibits the proliferation of SK-MEL-103 and SK-MEL-2 NRAS^Q61R melanoma cells, with IC₅₀ values of 29.97 μM and 11.73 μM, respectively^[1].

Others

CK1δ ligand-1 (5 μM; 24 h) induces 2% CK1δ degradation in SK-MEL-103 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SK-MEL-103 cells harboring NRASQ61R
Concentration:

5 μM
Incubation Time:

24 h
Result:

Caused 2% CK1δ degradation in SK-MEL-103 cells.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

Molecular Weight 352.41
Formula C₁₉H₂₁FN₆
SMILES

FC1=CC=C(C2=C(C3=NC(N)=NC=C3)N(CC4CCNCC4)C=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Changfa Zhang, et al. Discovery and Synthesis of Selective Casein Kinase 1δ Degraders for Suppressing Oncogenic NRAS-Mutant Melanoma. J. Med. Chem. 2026;

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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