CL-82198 hydrochloride
Based on 9 publication(s) in Google Scholar
CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE.
For research use only. We do not sell to patients.
- Purity : 99.58%
- CAS No.: 1188890-36-9
- Formula: C17H23ClN2O3
- Molecular Weight:338.83
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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NSC 405020MMP14 Inhibitor -
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MMP-9-IN-1MMP-9 Inhibitor -
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CL-82198MMP-13 Inhibitor -
HY-103444
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Publications Citing Use of MedChemExpress (MCE) CL-82198 hydrochloride
More- Nat Biomed Eng. 2025 May 16. [Abstract]
- Cell Stem Cell. 2023 May 4;30(5):648-664.e8. [Abstract]
- Nat Commun. 2026 Jun 11. [Abstract]
- Nat Commun. 2022 Jul 11;13(1):4007. [Abstract]
- Mar Drugs. 2023 Jul 31;21(8):433. [Abstract]
- J Cell Physiol. 2019 Sep;234(9):15395-15406. [Abstract]
- Biol Reprod. 2025 Apr 13;112(4):709-727. [Abstract]
- bioRxiv. 2025 Sep 21:2025.09.18.677154. [Abstract]
- Patent. US20240271130A1.
Biological Activity
Description
IC50 & Target
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MMP13 |
Chemical Information
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CAS No. 1188890-36-9
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Appearance Solid
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Molecular Weight 338.83
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Formula C17H23ClN2O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=C(C=CC=C2)O1)NCCCCN3CCOCC3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (9)
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Journal Impact Factor
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Most Recent
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Nat Biomed Eng
siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs. [Abstract]2025 May 16. PMID: 40379798 -
Cell Stem Cell
Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. [Abstract]2023 May 4;30(5):648-664.e8. PMID: 37146584 -
Nat Commun
Bone-derived Osterix+ osteolineage cells are a source of tumor-promoting myofibroblastic cancer-associated fibroblasts in breast cancer. [Abstract]2026 Jun 11. PMID: 42277024 -
Nat Commun
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance. [Abstract]2022 Jul 11;13(1):4007. PMID: 35817773 -
Mar Drugs
Astaxanthin: A Marine Drug That Ameliorates Cerebrovascular-Damage-Associated Alzheimer's Disease in a Zebrafish Model via the Inhibition of Matrix Metalloprotease-13. [Abstract]2023 Jul 31;21(8):433. PMID: 37623714 -
J Cell Physiol
2019 Sep;234(9):15395-15406. PMID: 30710340 -
Biol Reprod
Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways. [Abstract]2025 Apr 13;112(4):709-727. PMID: 39823285 -
bioRxiv
Myofibroblastic CAFs arising from bone-resident osteoblast precursors retain an osteolineage signature and support breast cancer progression via Osterix-mediated signaling. [Abstract]2025 Sep 21:2025.09.18.677154. PMID: 41279302 -
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (295.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9513 mL | 14.7567 mL | 29.5133 mL | 73.7833 mL |
| 5 mM | 0.5903 mL | 2.9513 mL | 5.9027 mL | 14.7567 mL | |
| 10 mM | 0.2951 mL | 1.4757 mL | 2.9513 mL | 7.3783 mL | |
| 15 mM | 0.1968 mL | 0.9838 mL | 1.9676 mL | 4.9189 mL | |
| 20 mM | 0.1476 mL | 0.7378 mL | 1.4757 mL | 3.6892 mL | |
| 25 mM | 0.1181 mL | 0.5903 mL | 1.1805 mL | 2.9513 mL | |
| 30 mM | 0.0984 mL | 0.4919 mL | 0.9838 mL | 2.4594 mL | |
| 40 mM | 0.0738 mL | 0.3689 mL | 0.7378 mL | 1.8446 mL | |
| 50 mM | 0.0590 mL | 0.2951 mL | 0.5903 mL | 1.4757 mL | |
| 60 mM | 0.0492 mL | 0.2459 mL | 0.4919 mL | 1.2297 mL | |
| 80 mM | 0.0369 mL | 0.1845 mL | 0.3689 mL | 0.9223 mL | |
| 100 mM | 0.0295 mL | 0.1476 mL | 0.2951 mL | 0.7378 mL |
CL-82198 hydrochloride Related Classifications
HY-110046 Related Classifications
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