Clorgyline hydrochloride (Standard)
Clorgyline hydrochloride (Standard) (M&B 9302 hydrochloride (Standard)) is the analytical standard of Clorgyline hydrochloride (HY-14197A). This product is intended for research and analytical applications. Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 17780-75-5
- Formula: C13H16Cl3NO
- Molecular Weight:308.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 17780-75-5
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Molecular Weight 308.63
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Formula C13H16Cl3NO
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SMILES
C#CCN(CCCOC1=CC=C(Cl)C=C1Cl)C.[H]Cl
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Synonyms
M&B 9302 hydrochloride (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Knoll J. The possible mechanisms of action of (-)deprenyl in Parkinson's disease. J Neural Transm. 1978;43(3-4):177-98. [Content Brief]
[5]. Seymour CB, et al. Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity. British journal of cancer. 2003 Nov 17;89(10):1979-86. [Content Brief]
[7]. Feldman JM, et al. Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice. Behavioural brain research. 1988 Jul;29(1-2):147-58. [Content Brief]
[8]. Campbell IC, et al. The effects of chronic regimens of clorgyline and pargyline on monoamine metabolism in the rat brain. J Neurochem. 1979 Jan;32(1):49-55. [Content Brief]
[9]. Green AR, et al. Effects of monoamine oxidase inhibition by clorgyline, deprenil or tranylcypromine on 5-hydroxytryptamine concentrations in rat brain and hyperactivity following subsequent tryptophan administration. British journal of pharmacology. 1975 Nov;55(3):415-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Clorgyline hydrochloride (Standard)
- 17780-75-5
- M&B 9302 hydrochloride (Standard)
- Reference Standards
- Monoamine Oxidase
- 5-HT Receptor
- Bcl-2 Family
- dopamine
- Huntington disease
- E-CA-90
- acetylcholine
- serotonin receptors
- monoamine oxidase A
- high grade prostate cancer
- HaCaT cells
- E-CA-88
- Syrian hamsters
- Inhibitor
- inhibitor
- inhibit