Colistin B
Colistin B (Polymyxin E2) is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B exerts apoptotic effects on human renal proximal tubular cells. Colistin B induces mild to moderate renal histological damage in mouse models. Colistin B can be used in the research of multidrug-resistant Gram-negative bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 7239-48-7
- Formula: C52H98N16O13
- Molecular Weight:1155.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
244 μg/mL
Compound: Colistin B
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Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 29412662] |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (22 to 28 g; neutropenic; challenged intravenously with Pseudomonas aeruginosa ATCC 27853)[1]
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Dosage:4 mg/kg
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Administration:i.v.; single dose
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Result:Achieved a mean reduction in blood bacterial burden of -3.99 log10 CFU/mL relative to saline control.
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Animal Model:Mice[1]
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Dosage:12 mg/kg; accumulated dose of 72 mg/kg
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Administration:s.c.; every 2 hours
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Result:Caused renal histological damage scored as semi-quantitative score (SQS) +1 to +2, corresponding to mild to moderate acute tubular damage including tubular dilation, degeneration, necrosis of tubular epithelial cells, and tubular casts.
Chemical Information
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CAS No. 7239-48-7
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Molecular Weight 1155.43
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Formula C52H98N16O13
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SMILES
CC(C)CCCCC(N[C@@H](CCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCN)C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC1)=O)([H])[C@H](O)C)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)=O)=O)=O
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Synonyms
Polymyxin E2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Colistin B Related Classifications
HY-184858 Related Classifications
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Keywords
- Colistin B
- 7239-48-7
- Polymyxin E2
- Polymyxin E 2
- Polymyxin E-2
- Bacterial
- Apoptosis
- mouse models
- Pseudomonas aeruginosa
- multidrug-resistant Gram-negative bacteria
- Acinetobacter baumannii
- human kidney proximal tubular cells
- multidrug-resistant Gram-negative bacterial infections
- Klebsiella pneumoniae
- neutropenic mice
- Enterobacter cloacae
- HK-2 cells
- Inhibitor
- inhibitor
- inhibit