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Cat. No.: HY-12863B

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CPI-0610 carboxylic acid

Name: CPI-0610 carboxylic acid
Brand: MedChemExpress
SKU: HY-12863B
Price: 380.00 USD
Availability: InStock
Rating: 5 (1 reviews)

CPI-0610 carboxylic acid is a novel small-molecule bromodomain and extraterminal protein inhibitor for the treatment of multiple myeloma. CPI-0610 carboxylic acid binds to the N-terminal bromodomains of BRD2, BRD3, BRD4, and BRDT, as well as the BRD9 bromodomain. CPI-0610 carboxylic acid can serve as a target protein ligand for the synthesis of PROTAC. CPI-0610 carboxylic acid can be used for research on multiple myeloma, acute myeloid leukemia, and lung and cervical cancers.

For research use only. We do not sell to patients.

CAS No.: 1380089-81-5
Formula: C₂₀H₁₅ClN₂O₃
Molecular Weight:366.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (290 KB)

CPI-0610 carboxylic acid Chemical Structure

CAS No.: 1380089-81-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]

BRD2

BRD3

BRD4

BRDT

BRD9

All Epigenetic Reader Domain Isoforms :

In Vitro

CPI-0610 carboxylic acid binds to the N-terminal bromodomains of BRD2, BRD3, BRD4, and BRDT, as well as the BRD9 bromodomain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1380089-81-5
Molecular Weight 366.80
Formula C₂₀H₁₅ClN₂O₃
SMILES

O=C(O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3C4=C1ON=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siu KT, et al. Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma. Leukemia. 2017 Aug;31(8):1760-1769. [Content Brief]

[2]. Wellaway CR, et al. Structure-based design of a bromodomain and extraterminal domain (BET) inhibitor selective for the N-terminal bromodomains that retains an anti-inflammatory and antiproliferative phenotype. Journal of Medicinal Chemistry. 2020 Aug 3;63(17):9020-44.

[3]. Wilson B, et al. Developing small molecule inhibitors of bromodomain-histone interactions (Doctoral dissertation, University of Oxford).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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