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Cat. No.: HY-W013274S

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CPTH2-d₄

Name: CPTH2-d4
Brand: MedChemExpress
SKU: HY-W013274S
Price: 1170.00 USD
Availability: InStock
Rating: 5 (1 reviews)

CPTH2-d₄ is the deuterated-labeled CPTH2 (HY-W013274). CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B).

For research use only. We do not sell to patients.

Formula: C₁₄H₁₀D₄ClN₃S
Molecular Weight:295.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CPTH2-d₄ Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Histone Acetyltransferase Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 357649-93-5
Molecular Weight 295.82
Formula C₁₄H₁₀D₄ClN₃S
SMILES

ClC1=C([2H])C([2H])=C(C2=CSC(N/N=C3CCCC/3)=N2)C([2H])=C1[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. [Content Brief]

[2]. Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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CPTH2-d4

All Histone Acetyltransferase Isoforms