country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P12373

Copy Link Print Information

CQPQGLAKC

CQPQGLAKC is a peptide crosslinker and hydrogel component that can be cleaved by MMP. The degradation of CQPQGLAKC is primarily mediated by endogenous MMP-13, with a K_m value of 1.10 µM. CQPQGLAKC crosslinks hyaluronic acid hydrogels via Michael-type addition, thereby enabling cell-mediated matrix remodeling and promoting cell survival, proliferation, and endothelial differentiation. CQPQGLAKC can be used in research on rotator cuff tears and ischemic injury.

For research use only. We do not sell to patients.

CAS No.: 1620389-76-5
Formula: C₃₈H₆₆N₁₂O₁₂S₂
Molecular Weight:947.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CQPQGLAKC Chemical Structure

CAS No.: 1620389-76-5

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

MMP13

1.10 μM (Km)

All MMP Isoforms :

In Vitro

QPQGLAK is a slowly degradable MMP-sensitive peptide crosslinker with the lowest k_cat/K_m for MMP-13 (7.5 x 10² s^-1 M^-1) compared to MMP-2 and MMP-9^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1620389-76-5
Molecular Weight 947.13
Formula C₃₈H₆₆N₁₂O₁₂S₂
SMILES

O=C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
Sequence

Cys-Gln-Pro-Gln-Gly-Leu-Ala-Lys-Cys
Sequence Shortening

CQPQGLAKC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Natividad-Diaz SL, et al. A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis. Biomaterials. 2019 Feb;194:73-83.

[2]. Jha AK, et al. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials. 2016 May;89:136-47.

[3]. Pfaff MR, et al. Viscoelastic HyA Hydrogel Promotes Recovery of Muscle Quality and Vascularization in a Murine Model of Delayed Rotator Cuff Repair. Advanced healthcare materials. 2025 Apr;14(10):e2403962.

[4]. Browne S, et al. TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. PloS one. 2018;13(3):e0194679.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

CQPQGLAKC

All MMP Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CQPQGLAKC Related Classifications

HY-P12373 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target