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Cat. No.: HY-189452

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CRBN ligand-909

CRBN ligand-909 is an E3 ligase ligand and can be used in the synthesis of PROTAC apPHOTAC-I-2C (HY-189451).

For research use only. We do not sell to patients.

Formula: C₁₈H₁₈N₆O₃
Molecular Weight:366.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN ligand-909 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

CRBN ligand-909 is an E3 ligase ligand and can be used in the synthesis of PROTAC apPHOTAC-I-2C (HY-189451)^[1].

All Ligands for E3 Ligase Isoforms :

In Vitro

PROTACs comprise two distinct ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase, and the other is a ligand for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 366.37
Formula C₁₈H₁₈N₆O₃
SMILES

O=C1NC(CCC1N2CC(C(/N=N/C3=C(C)NN=C3C)=CC=C4)=C4C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Flores J, et al. Optimizing CRBN-ligands for Optical Targeted Protein Degradation[J]. RSC Medicinal Chemistry, 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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