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Cat. No.: HY-190238

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CRBN ligand-913

CRBN ligand-913 (compound D10) is a molecular glue degrader that binds to the CRL4^CRBN E3 ubiquitin ligase.

For research use only. We do not sell to patients.

CAS No.: 3077971-60-6
Formula: C₃₀H₃₀FN₅O₄
Molecular Weight:543.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN ligand-913 Chemical Structure

CAS No.: 3077971-60-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

CRBN ligand-913 (compound D10) is a molecular glue degrader that binds to the CRL4^CRBN E3 ubiquitin ligase^[1].

IC₅₀ & Target

^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

Molecular glues are a class of protein degraders based on the ubiquitin-proteasome pathway. Molecular glues are a class of small-molecule compounds capable of inducing or stabilizing protein-protein interactions. If one of the proteins is a ubiquitin ligase, molecular glues can cause the other protein to undergo ubiquitin modification and degradation via the proteasome pathway, similar to PROTACs. However, in subsequent classifications, these molecules are categorized as functional molecules that serve as ligands for E3 ligases.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3077971-60-6
Molecular Weight 543.59
Formula C₃₀H₃₀FN₅O₄
SMILES

O=C(C(N1NC2=C(C=CC=C2OCC3=CC=C(CN4CCN(C5=CC=C(F)C=C5)CC4)C=C3)C1=O)CC6)NC6=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Preparation of indazolone compounds, pharmaceutical compositions and applications thereof. CN119613374 A. Published 2025 Mar 14.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CRBN ligand-913

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CRBN ligand-913 Related Classifications

HY-190238 Related Classifications

Bioz

Keywords

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