country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-190244

Copy Link Print Information

CRBN ligand-914

CRBN ligand-914 (compound 1) is a molecular glue that acts as a ligand binding to the cereblon (CRBN) protein. CRBN ligand-914 binds to CRBN, the substrate receptor of the E3 ubiquitin ligase CRL4, thereby mediating the ubiquitination and proteasomal degradation of recruited target proteins. CRBN ligand-914 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3084433-93-9
Formula: C₁₈H₁₉N₃O₆
Molecular Weight:373.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN ligand-914 Chemical Structure

CAS No.: 3084433-93-9

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

Molecular glues are a class of small-molecule compounds that induce or stabilize novel protein-protein interactions (PPIs) between proteins that inherently lack natural affinity for one another within cells. By remodeling the spatial topology of protein complexes, they achieve functional regulation of target proteins, structural stabilization, or specific degradation dependent on the ubiquitin-proteasome system.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3084433-93-9
Molecular Weight 373.36
Formula C₁₈H₁₉N₃O₆
SMILES

C[C@@H](NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CC(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Su-kyung Hwang, et al. Novel molecular glues and uses thereof. CN119431311A. CNIPA. 2025-02-14.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

CRBN ligand-914

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CRBN ligand-914 Related Classifications

HY-190244 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target