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Cat. No.: HY-172981

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CTW0404

CTW0404 is a 5-HT_2AR positive allosteric modulator that enhances Serotonin (HY-B1473A)-induced intracellular calcium release without intrinsic agonist activity. CTW0404 attenuates head-twitch responses but does not induce head twitches by itself. CTW0404 can be used for research on neuropsychiatric disorders.

For research use only. We do not sell to patients.

CAS No.: 2913202-87-4
Formula: C₂₁H₃₃N₃O₂
Molecular Weight:359.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

CTW0404 Chemical Structure

CAS No.: 2913202-87-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

5-HT_2A Receptor

All 5-HT Receptor Isoforms :

In Vitro

CTW0404 acts as a 5-HT_2AR PAM in h5-HT_2AR-expressing stable cell lines, enhancing 5-HT-induced intracellular calcium release without intrinsic agonist activity and lacking activity at h5-HT_2BR and h5-HT_2CR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CTW0404 does not produce (-)-DOI-like interoceptive effects in rats^[1].
CTW0404 lacks head-twitch-inducing activity and attenuates (-)-DOI-evoked head twitches in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2913202-87-4
Molecular Weight 359.51
Formula C₂₁H₃₃N₃O₂
SMILES

O=C(C1CC(CCN1)CCC2=CC=CC=C2)NCCCN3CCOCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zamora J C, et al. Serendipitous Discovery of Novel 5-HT2AR Positive Allosteric Modulators (PAMs) Derived From 5-HT2CR PAM Scaffolds[J]. The Journal of Pharmacology and Experimental Therapeutics, 2024, 389: 87.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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