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Cat. No.: HY-177629D

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Cy3 labled Elsunersen sodium

Cy3 labled Elsunersen sodium refers to Elsunersen sodium (HY-177629A) tagged with the fluorescent dye Cy3 (HY-D0822). Elsunersen sodium (PRAX‑222 sodium) is a gapmer antisense oligonucleotide targeting SCN2A mRNA. Elsunersen sodium reduces the protein level of the voltage-gated sodium channel Na_V1.2 by degrading SCN2A mRNA, alleviating neuronal network hyperexcitability. Elsunersen sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency. Elsunersen sodium can be used in research related to epileptic encephalopathy.

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Cy3 labled Elsunersen sodium Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[1]

Nav1.2

All Sodium Channel Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

Elsunersen sodium degrades SCN2A mRNA and downregulates Na_V1.2 protein expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Elsunersen (intrathecal administration) sodium combined with sodium channel blockers terminates refractory status epilepticus and reduces seizure frequency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2242 KB)

References

[1]. Frizzo S, et al. Complementary Antisense Oligonucleotide Treatment and Precision Sodium Channel Modulation for Early Onset SCN2A Developmental and Epileptic Encephalopathy: Emergency Use Case in a Preterm Infant with Refractory Status Epilepticus (P10-11.009). Neurology. 2026;106(11 Suppl 1):2271.

[2]. Potschka H, et al. Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies. Epilepsia. 2025 Dec;66(12):4597-4623.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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