Cyclam
Based on 1 publication(s) in Google Scholar
Cyclam is a macrocyclic polyamine that can serve as a high-affinity chelator for Cu2+ and a CXCR4-targeting motif. Cyclam is the CXCR4-binding unit of the CXCR4 antagonist Plerixafor (AMD3100) (HY-10046). Cyclam-based macrocyclic compounds possess anti-HIV activity and can mobilize stem cells from the bone marrow. Cyclam can be used in research on ovarian cancer with high CXCR4 expression, as well as in the development of Cu2+ sensors and lanthanide luminescent bioprobes.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 295-37-4
- Formula: C10H24N4
- Molecular Weight:200.33
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Cyclam
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Biological Activity
Description
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HIV |
CXCR4 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 295-37-4
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Appearance Solid
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Molecular Weight 200.33
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Formula C10H24N4
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Color White to yellow
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SMILES
N1CCNCCCNCCNCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
In Vitro:
H2O : 20 mg/mL (99.84 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9918 mL | 24.9588 mL | 49.9176 mL | 124.7941 mL |
| 5 mM | 0.9984 mL | 4.9918 mL | 9.9835 mL | 24.9588 mL | |
| 10 mM | 0.4992 mL | 2.4959 mL | 4.9918 mL | 12.4794 mL | |
| 15 mM | 0.3328 mL | 1.6639 mL | 3.3278 mL | 8.3196 mL | |
| 20 mM | 0.2496 mL | 1.2479 mL | 2.4959 mL | 6.2397 mL | |
| 25 mM | 0.1997 mL | 0.9984 mL | 1.9967 mL | 4.9918 mL | |
| 30 mM | 0.1664 mL | 0.8320 mL | 1.6639 mL | 4.1598 mL | |
| 40 mM | 0.1248 mL | 0.6240 mL | 1.2479 mL | 3.1199 mL | |
| 50 mM | 0.0998 mL | 0.4992 mL | 0.9984 mL | 2.4959 mL | |
| 60 mM | 0.0832 mL | 0.4160 mL | 0.8320 mL | 2.0799 mL | |
| 80 mM | 0.0624 mL | 0.3120 mL | 0.6240 mL | 1.5599 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclam Related Classifications
HY-D0179 Related Classifications
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