D-4'-Phosphopantothenate
D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A. The expression level of D-4'-Phosphopantothenate is downregulated in macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate. D-4'-Phosphopantothenate is positively correlated with the sucrose preference index in mice subjected to chronic unpredictable mild stress (CUMS), and its expression can be upregulated by the aqueous extract of Cistanche tubulosa. D-4'-Phosphopantothenate can be used in studies related to depression comorbid with sexual dysfunction.
For research use only. We do not sell to patients.
- CAS No.: 5875-50-3
- Formula: C9H18NO8P
- Molecular Weight:299.21
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
D-4'-Phosphopantothenate is downregulated in RAW 264.7 mouse macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5875-50-3
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Appearance Solid
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Molecular Weight 299.21
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Formula C9H18NO8P
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Color White to off-white
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SMILES
O=P(O)(O)OCC(C)(C)[C@@H](O)C(NCCC(O)=O)=O
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Synonyms
Phosphopantothenic acid; 4'-Phosphopantothenate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 25 mg/mL (83.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3421 mL | 16.7107 mL | 33.4213 mL | 83.5534 mL |
| 5 mM | 0.6684 mL | 3.3421 mL | 6.6843 mL | 16.7107 mL | |
| 10 mM | 0.3342 mL | 1.6711 mL | 3.3421 mL | 8.3553 mL | |
| 15 mM | 0.2228 mL | 1.1140 mL | 2.2281 mL | 5.5702 mL | |
| 20 mM | 0.1671 mL | 0.8355 mL | 1.6711 mL | 4.1777 mL | |
| 25 mM | 0.1337 mL | 0.6684 mL | 1.3369 mL | 3.3421 mL | |
| 30 mM | 0.1114 mL | 0.5570 mL | 1.1140 mL | 2.7851 mL | |
| 40 mM | 0.0836 mL | 0.4178 mL | 0.8355 mL | 2.0888 mL | |
| 50 mM | 0.0668 mL | 0.3342 mL | 0.6684 mL | 1.6711 mL | |
| 60 mM | 0.0557 mL | 0.2785 mL | 0.5570 mL | 1.3926 mL | |
| 80 mM | 0.0418 mL | 0.2089 mL | 0.4178 mL | 1.0444 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-4'-Phosphopantothenate Related Classifications
HY-165471 Related Classifications
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Keywords
- D-4'-Phosphopantothenate
- 5875-50-3
- Phosphopantothenic acid
- 4'-Phosphopantothenate
- Endogenous Metabolite
- Drug Intermediate
- macrophages
- sulfo-N-succinimidyl oleate
- Candidatus Entoporibacteria
- CD36
- CUMS mice
- RAW 264.7 mouse macrophages
- coenzyme A
- pantothenate and coenzyme A biosynthesis pathway
- Cistanche tubulosa
- graphene nanoplatelets
- Inhibitor
- inhibitor
- inhibit