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Cat. No.: HY-P3549

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[D-Ala2] Leu-Enkephalinamide

[D-Ala2] Leu-Enkephalinamide is an enkephalin analog. [D-Ala2] Leu-Enkephalinamide has great corneal permeability and analgesic effect. [D-Ala2] Leu-Enkephalinamide can be used for the research of ocular diseases.

For research use only. We do not sell to patients.

CAS No.: 65189-64-2
Formula: C₂₉H₄₀N₆O₆
Molecular Weight:568.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

[D-Ala2] Leu-Enkephalinamide Chemical Structure

CAS No.: 65189-64-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

[D-Ala2] Leu-Enkephalinamide (MEA) (1.0 mM; 10-240 min) has great corneal permeability in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-Ala2-Leu-enkephalinamide (s.c.) is also enhanced in morphine-dependent animals^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Transepithelial/transendothelial electrical resistance assay

Chemical Information

CAS No. 65189-64-2
Molecular Weight 568.66
Formula C₂₉H₄₀N₆O₆
Sequence Shortening

Y-{d-Ala}-GFL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. V P Ranta, et al. Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection II. Application to ocular permeability studies in vitro. J Chromatogr B Biomed Sci Appl. 1998 May 8;709(1):1-10. [Content Brief]

[2]. L S Brady, et al. Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats. J Pharmacol Exp Ther. 1982 Jul;222(1):190-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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