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Cat. No.: HY-N1914A

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D-Ergothioneine

Name: D-Ergothioneine
Brand: MedChemExpress
SKU: HY-N1914A
Availability: PreOrder

14 Cited Publications

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Based on 14 publication(s) in Google Scholar

D-Ergothioneine is a D-enantiomer of Ergothioneine (HY-N1914). Ergothioneine is an orally active imidazole-2-thione derivative of histidine betaine.

For research use only. We do not sell to patients.

CAS No.: 1352002-59-5
Formula: C₉H₁₅N₃O₂S
Molecular Weight:229.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D-Ergothioneine Chemical Structure

CAS No.: 1352002-59-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

D-Ergothioneine is a D-enantiomer of Ergothioneine (HY-N1914). Ergothioneine is an orally active imidazole-2-thione derivative of histidine betaine^[1].

Chemical Information

CAS No. 1352002-59-5
Molecular Weight 229.30
Formula C₉H₁₅N₃O₂S
SMILES

S=C1NC(C[C@H](C([O-])=O)[N+](C)(C)C)=CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (14)

All Cell Imaging/StainingCell Proliferation/Viability AssayFlow CytometryApoptosis AnalysisWB

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Journal Impact Factor

Redox Biol

Ergothioneine rescues obesity-induced testicular dysfunction via dual restoration of steroidogenesis and mitochondrial redox homeostasis. [Abstract]

2026 Apr:91:104090. PMID: 41719756
Mol Biomed

Ergothioneine attenuates whole-abdominal irradiation-induced multi-organ injury via the gut-heart-brain axis by modulating calcium voltage-gated channel subunit alpha1 C (Cacna1c) expression. [Abstract]

2026 Jan 14;7(1):6. PMID: 41530565
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
ACS Appl Mater Interfaces

Ergothioneine-Sodium Hyaluronate Dressing: A Promising Approach for Protecting against Radiation-Induced Skin Injury. [Abstract]

2024 Jun 12;16(23):29917-29929. PMID: 38813785

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Ergothioneine (EGT; 40 μg/mL; 48h). Fluorescence images of live/dead staining.

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Ergothioneine (EGT; 40 μg/mL; 0-6 days). Survival fraction at different radiation dosages by colony formation assay.

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Ergothioneine (EGT; 40 μg/mL; 24 h). Analysis of DCF fluorescence by flow cytometry.

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Ergothioneine (EGT; 40 μg/mL; 24 h). Statistics of apoptosis rate.

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Ergothioneine (EGT; 40 μg/mL; 24 h). Expression of Bcl-2, Bax, c-Caspase-3, and c-PARP following varying treatments.
ACS Appl Mater Interfaces

Adhesive Ergothioneine Hyaluronate Gel Protects against Radiation Gastroenteritis by Alleviating Apoptosis, Inflammation, and Gut Microbiota Dysbiosis. [Abstract]

2023 Apr 26;15(16):19833-19846. PMID: 37052616
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Antioxid Redox Signal

The antioxidant ergothioneine alleviates cisplatin-induced hearing loss through the Nrf2 pathway. [Abstract]

2025 Jan;42(1-3):97-114. PMID: 38770822
Environ Microbiome

2026 Jun 1;21(1):97. PMID: 42226086
Int Immunopharmacol

Ergothioneine inhibits the progression of osteoarthritis via the Sirt6/NF-κB axis both in vitro and in vivo. [Abstract]

2023 Jun:119:110211. PMID: 37156032
Sci Rep

Ergothioneine promotes osteogenesis and angiogenesis through PI3K/AKT pathway and prevents glucocorticoid-induced osteonecrosis of the femoral head. [Abstract]

2026 Feb 28;16(1):11411. PMID: 41764247
Hum Exp Toxicol

Anti-EMT properties of ergothioneine attenuate lipopolysaccharide-induced oxidative stress-mediated acute lung injury via modulating TGF-β/smad/snail signaling pathway. [Abstract]

2023 Jan-Dec:42:9603271231178015. PMID: 37212426
SSRN

2025 Nov 17.
bioRxiv

2025 June 02.
bioRxiv

2025 April 08.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Erdelmeier I, et al. Cysteine as a sustainable sulfur reagent for the protecting-group-free synthesis of sulfur-containing amino acids: biomimetic synthesis of L-ergothioneine in water[J]. Green Chemistry, 2012, 14(8): 2256-2265.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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D-Ergothioneine

14 Cited Publications

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Publications (14)
Purity & Documentation
References

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D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Customer Validation
Ergothioneine (EGT; 40 μg/mL; 48h). Fluorescence images of live/dead staining.
1/16

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Customer Validation
Ergothioneine (EGT; 40 μg/mL; 0-6 days). Survival fraction at different radiation dosages by colony formation assay.
1/16

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Customer Validation
Ergothioneine (EGT; 40 μg/mL; 24 h). Analysis of DCF fluorescence by flow cytometry.
1/16

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Customer Validation
Ergothioneine (EGT; 40 μg/mL; 24 h). Statistics of apoptosis rate.
1/16

D-Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]

Customer Validation
Ergothioneine (EGT; 40 μg/mL; 24 h). Expression of Bcl-2, Bax, c-Caspase-3, and c-PARP following varying treatments.

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D-Ergothioneine

Publications Citing Use of MedChemExpress (MCE) D-Ergothioneine

Biological Activity

Description

Chemical Information

Publications (14)

Purity & Documentation

References

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D-Ergothioneine

Publications Citing Use of MedChemExpress (MCE) D-Ergothioneine

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Description

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Publications (14)

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