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Cat. No.: HY-184878

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D-Erythro-sphingosine-1-phosphate

D-Erythro-sphingosine-1-phosphate is a phosphorylated sphingoid base and catabolic intermediate. As a component of the intracellular second messenger system, D-Erythro-sphingosine-1-phosphate induces rapid translocation of calcium ions in fibroblasts and acts as a mitogen. D-Erythro-sphingosine-1-phosphate also effectively inhibits the motility of melanoma cells, and can be used in the research of melanoma and other related diseases.

For research use only. We do not sell to patients.

CAS No.: 528852-49-5
Formula: C₁₈H₃₈NO₅P
Molecular Weight:379.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D-Erythro-sphingosine-1-phosphate Chemical Structure

CAS No.: 528852-49-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

OthersAnti-cancer

Others

D-Erythro-sphingosine-1-phosphate potently induces mitogenic activity in Swiss 3T3 fibroblasts^[1].
D-Erythro-sphingosine-1-phosphate rapidly induces calcium release from intracellular stores in unspecified cells^[1].

Anti-cancer

D-Erythro-sphingosine-1-phosphate (10 nM) inhibits motility of melanoma cells, while sphingosine has no effect at this concentration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 528852-49-5
Molecular Weight 379.48
Formula C₁₈H₃₈NO₅P
SMILES

[C@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)(COP(=O)(O)O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Boumendjel A, Miller S P. Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate[J]. Journal of lipid research, 1994, 35(12): 2305-2311.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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