DBCO-PEG4-GGFG-Triptolide
DBCO-PEG4-GGFG-Triptolide is a triptolide-based antibody-drug conjugate (ADC) payload, consisting of a DBCO click chemistry reactive group, a PEG4 linker, a cathepsin-cleavable GGFG peptide segment, and triptolide. DBCO-PEG4-GGFG-Triptolide binds to antibodies via glycosylation conjugation, releases active triptolide intracellularly to exert cytotoxic effects, and is commonly used in combination with camptothecin-class toxins (Exatecan (HY-13631) / DXd (HY-13631D)) for the preparation of dual-toxin ADCs.
For research use only. We do not sell to patients.
- Purity : 98.83%
- CAS No.: 3086791-85-4
- Formula: C68H81N7O19
- Molecular Weight:1300.41
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3086791-85-4
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Appearance Solid
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Molecular Weight 1300.41
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Formula C68H81N7O19
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Color White to off-white
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SMILES
C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OC(COCNC(CNC([C@H](CC8=CC=CC=C8)NC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N9CC%10=CC=CC=C%10C#CC%11=CC=CC=C%119)=O)=O)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (38.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.7690 mL | 3.8449 mL | 7.6899 mL | 19.2247 mL |
| 5 mM | 0.1538 mL | 0.7690 mL | 1.5380 mL | 3.8449 mL | |
| 10 mM | 0.0769 mL | 0.3845 mL | 0.7690 mL | 1.9225 mL | |
| 15 mM | 0.0513 mL | 0.2563 mL | 0.5127 mL | 1.2816 mL | |
| 20 mM | 0.0384 mL | 0.1922 mL | 0.3845 mL | 0.9612 mL | |
| 25 mM | 0.0308 mL | 0.1538 mL | 0.3076 mL | 0.7690 mL | |
| 30 mM | 0.0256 mL | 0.1282 mL | 0.2563 mL | 0.6408 mL |
DBCO-PEG4-GGFG-Triptolide Related Classifications
HY-188015 Related Classifications
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