(+)-Decanoylcarnitine
(+)-Decanoylcarnitine is an (S)-acylcarnitine derivative and a potent inhibitor of carnitine-acylcarnitine translocase, with an IC50 of 5 μM. (+)-Decanoylcarnitine acts as a competitive inhibitor of long-chain acylcarnitine transferase and (-)-carnitine palmityltransferase. (+)-Decanoylcarnitine blocks hepatic fatty acid oxidation, ketogenesis, oleate-induced activation of gluconeogenesis, as well as associated changes in acetyl-CoA, citrate, redox pair ratios, flavins and pyridine nucleotides. (+)-Decanoylcarnitine reverses ketosis in vivo, enhances insulin-mediated hypoglycemic effects in anesthetized animals, and reduces plasma ketone body levels when used in combination with insulin. (+)-Decanoylcarnitine can be used in studies related to diabetic ketoacidosis.
For research use only. We do not sell to patients.
- CAS No.: 25518-51-8
- Formula: C17H33NO4
- Molecular Weight:315.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
(+)-Decanoylcarnitine (20 mg/mL; intravenous injection; single injection duration of 2 min) reduces plasma ketone bodies more rapidly than insulin alone in unanesthetized, non-intubated alloxan-diabetic rats with ketoacidosis when used alone[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, initial weight ~130 g, weight ~100 g at experiment start, alloxan-induced diabetic ketoacidosis)[1]
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Dosage:20 mg/mL
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Administration:i.v.; 75 μl/min for 10 min then 10 μl/min until 2 h
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Result:Reduced plasma ketone levels from an initial 1,502 μmol/100 mL to 262 μmol/100 mL over 4 hours.
When combined with insulin, reduced plasma ketones from an initial 1,532 μmol/100 mL to 69 μmol/100 mL over 4 hours.
Had no effect on plasma glucose, with levels remaining at ~1,043-1,045 mg/100 mL over 4 hours.
When combined with insulin, reduced plasma glucose from an initial 896 mg/100 mL to 281 mg/100 mL over 4 hours.
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Animal Model:Sprague-Dawley (male, initial weight ~130 g, weight ~100 g at experiment start, alloxan-induced diabetic ketoacidosis)[1]
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Dosage:20 mg/mL
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Administration:i.v.; 10 min infusion
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Result:Reduced plasma ketone levels from an initial 1,863 μmol/100 mL to 1,254 μmol/100 mL over 2 hours.
When combined with insulin, reduced plasma ketones from an initial 1,754 μmol/100 mL to 717 μmol/100 mL over 2 hours.
Had no effect on plasma glucose, and did not enhance insulin-induced hypoglycemia in awake animals.
Caused an increase in plasma free fatty acid levels, and blunted the insulin-induced fall in free fatty acids.
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Animal Model:Sprague-Dawley (male, initial weight ~130 g, weight ~100 g at experiment start, alloxan-induced diabetic ketoacidosis)[1]
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Dosage:20 mg/mL (0.5 mL total)
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Administration:i.v.; single injection over 2 min
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Result:Reduced plasma ketone levels at a faster rate than insulin alone.
The combination of (+)-Decanoylcarnitine and insulin produced a greater ketone reduction than either agent alone.
Had no effect on plasma glucose, and did not enhance insulin-induced hypoglycemia.
Did not blunt the insulin-induced fall in free fatty acids.
Chemical Information
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CAS No. 25518-51-8
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Molecular Weight 315.45
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Formula C17H33NO4
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SMILES
[C@@H](OC(CCCCCCCCC)=O)(C[N+](C)(C)C)CC([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-Decanoylcarnitine Related Classifications
HY-165175 Related Classifications
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