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Cat. No.: HY-N8890

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Demissidine

Name: Demissidine
Brand: MedChemExpress
SKU: HY-N8890
Price: 138.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Demissidine is an alkaloid aglycone that can be isolated from Solanum tuberosum. Demissidine is a dual inhibitor candidate that shows activity against β-secretase and γ-secretase in silico. Demissidine has antibacterial and antiparasitic activities. Demissidine also has weak anticancer and acetylcholinesterase (AChE) inhibitory activities. Demissidine can be used in research on colon cancer, liver cancer, Alzheimer's disease, and Chagas disease.

For research use only. We do not sell to patients.

Purity : 95%
CAS No.: 474-08-8
Formula: C₂₇H₄₅NO
Molecular Weight:399.65

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Demissidine Chemical Structure

CAS No.: 474-08-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[8]^[6]

Trypanosoma

electric eel AChE

All Endogenous Metabolite Isoforms :

All Beta-secretase Isoforms :

BACE1
BACE2

All Cholinesterase (ChE) Isoforms :

AChE
BChE

All Parasite Isoforms :

In Vitro

Anti-cancerBacterial InfectionParasitic InfectionOthers

Anti-cancer

Demissidine (0.1-100 µg/mL; 4 h) weakly inhibits the growth of HT29 human colon cancer cells and HepG2 human hepatoma cells, producing 30.3% and 56.8% growth inhibition, respectively, at 100 µg/mL^[1].

Bacterial Infection

Demissidine (62.5-1000 µg/mL) has an MIC of 250 µg/mL against Staphylococcus aureus ATCC No. 6538, an MIC of 2000 µg/mL against Klebsiella pneumoniae, an MIC of 4000 µg/mL against Bacillus subtilis and Escherichia coli, and an MIC of > 4000 µg/mL against Pseudomonas aeruginosa^[3].

Parasitic Infection

Demissidine (5.7 µM; observed on days 1-13) inhibits the growth of epimastigotes of the Trypanosoma cruzi EP strain in LIT medium, reaching 98.8% inhibition by day 12^[8].

Others

Demissidine (2 mg/L; 96 h), at its solubility limit, causes 0.0% mortality and 25.0% malformation rates in Xenopus embryos without metabolic activation, with no significant increase in toxicity or teratogenicity under MAS^[4].
Demissidine (30 s) inhibits electric eel acetylcholinesterase in vitro, producing a mean inhibition of 11.3% at 40.0 ppm^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human colon carcinoma HT29 cells and human liver carcinoma HepG2 cells
Concentration:

0.1, 1, 10, 100 µg/mL
Incubation Time:

4 h
Result:

Produced 30.3% and 56.8% growth inhibition at 100 µg/mL, respectively.

Related Protocols :

Chemical Information

CAS No. 474-08-8
Appearance Solid
Molecular Weight 399.65
Formula C₂₇H₄₅NO
Color White to light yellow
SMILES

C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5([C@@](C[C@H](CC5)O)([H])CC4)C)([H])CC2)([H])N6[C@@](CC[C@@H](C6)C)([H])[C@H]3C
Structure Classification
- Alkaloids
- Steroid Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee KR, et al. Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. Journal of agricultural and food chemistry. 2004 May 19;52(10):2832-9.

[2]. Onifade IA, et al. In silico study of selected alkaloids as dual inhibitors of β-and γ-secretases for Alzheimer's disease. Journal of Alzheimer’s Disease. 2025 Feb;103(4):1191-215. [Content Brief]

[3]. Niño J, et al. Biological activities of steroidal alkaloids isolated from Solanum leucocarpum. Pharmaceutical Biology. 2009 Mar 1;47(3):255-9.

[4]. Friedman M, et al. Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay--Xenopus (FETAX). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1991 Aug;29(8):537-47.

[5]. Dahlman DL, et al. Responses of Empoasca fabae (Cicadellidae: Homoptera) to tomatine, solanine, leptine I; tomatidine, solanidine, and demissidine. Annals of the Entomological Society of America. 1967 Jul 17;60(4):732-40.

[6]. Bushway RJ, et al. Inhibition of acetyl cholinesterase by solanaceous glycoalkaloids and alkaloids. American potato journal. 1987 Aug;64(8):409-13.

[7]. Krishnan N, et al. Compartmentalization of oxidative stress and antioxidant defense in the larval gut of Spodoptera littoralis. Archives of insect biochemistry and physiology. 2006 Sep;63(1):1-10.

[8]. Chataing B, et al. Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids: a comparison with ketoconazole. Planta medica. 1998 Feb;64(1):31-6.

[9]. Kenny OM, et al. Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages. Life sciences. 2013 Apr 19;92(13):775-82.

[10]. Garfield W. The significance of isomerism and stereospecificity to the chemistry of plant teratogens. Journal of Toxicology: Toxin Reviews. 1986 Jan 1;5(2):229-40.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Demissidine

All Endogenous Metabolite Isoforms

All Beta-secretase Isoforms

All Cholinesterase (ChE) Isoforms

All Parasite Isoforms