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Cat. No.: HY-N21639

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Deoxycaesaldekarin C

Name: Deoxycaesaldekarin C
Brand: MedChemExpress
SKU: HY-N21639
Availability: PreOrder

(Synonyms: Methyl vouacapenate)

Deoxycaesaldekarin C (Methyl vouacapenate) is a naturally occurring, orally active cassane furanoditerpene with antibacterial, antioxidant, antiplasmodial, and analgesic effects. Deoxycaesaldekarin C inhibits bacterial growth and lipid peroxidation, and scavenges free radicals. Deoxycaesaldekarin C exhibits weak antiplasmodial activity and shows analgesic activity in mouse in vivo models. Deoxycaesaldekarin C can be used in research related to pain, bacterial infections, and Plasmodium infections.

For research use only. We do not sell to patients.

CAS No.: 4614-50-0
Formula: C₂₁H₃₀O₃
Molecular Weight:330.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Deoxycaesaldekarin C Chemical Structure

CAS No.: 4614-50-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[2]

Plasmodium

All Parasite Isoforms :

In Vitro

Oxidative StressBacterial InfectionParasitic Infection

Oxidative Stress

Deoxycaesaldekarin C (compound 1) (12.5-200 μg/mL; 20 min) exhibits antioxidant activity, with DPPH radical scavenging IC₅₀ = 97.4 μM and TBA lipid peroxidation inhibition IC₅₀ = 134.8 μM^[1].

Bacterial Infection

Deoxycaesaldekarin C (1000-7.8 μg/mL; 24 h) exhibits antibacterial activity against a panel of bacteria, with the strongest effect against Bacillus subtilis (MIC = 47 μM)^[1].

Parasitic Infection

Deoxycaesaldekarin C (cpd 5) exhibits low to moderate antimalarial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) Plasmodium falciparum strains, with an IC₅₀ of 25.67 μM against D6 and an IC₅₀ of 30.33 μM against W2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Deoxycaesaldekarin C (compound 5) (100 mg/kg; i.p.; single administration; 60 min before Acetic acid) shows significant antinociceptive activity in the Acetic acid (HY-Y0319)-induced writhing model, with a writhing inhibition rate of 77.59%^[2].
Deoxycaesaldekarin C (100 mg/kg; i.p.; single administration) exhibits significant central antinociceptive activity in the hot-plate test^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino mice (20-25 g; either sex)^[2]
Dosage:

100 mg/kg
Administration:

i.p.; single dose; 60 min before acetic acid
Result:

Reduced the number of writhing episodes induced by Acetic acid by 77.59% compared to control.

Animal Model:

Swiss albino mice (17-30 g; either sex)^[2]
Dosage:

100 mg/kg
Administration:

i.p.; single dose
Result:

Showed significant central antinociceptive activity in the hot-plate test at 60 min relative to control.

Related Protocols :

Chemical Information

CAS No. 4614-50-0
Molecular Weight 330.46
Formula C₂₁H₃₀O₃
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])[C@](C)(CCC2)C(OC)=O)([H])[C@H](C4=C(OC=C4)C3)C
Synonyms

Methyl vouacapenate
Structure Classification
- Terpenoids
- Diterpenoids
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dickson RA, et al. Antibacterial and antioxidant cassane diterpenoids from Caesalpinia benthamiana. Phytochemistry. 2007 May;68(10):1436-41.

[2]. Ochieng' CO, et al. Antinociceptive and antiplasmodial activities of cassane furanoditerpenes from Caesalpinia volkensii H. root bark. Fitoterapia. 2012 Jan;83(1):74-80.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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