Deoxythymidine-5'-triphosphate trisodium solution (100 mM)
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Deoxythymidine-5'-triphosphate trisodium solution (100 mM) (dTTP trisodium solution (100 mM)) is a deoxyribonucleoside triphosphate and a thymidine analog, which serves as a direct precursor for DNA synthesis. Deoxythymidine-5'-triphosphate trisodium solution (100 mM) can be used for DNA amplification in the DNA polymerase chain reaction (PCR). Deoxythymidine-5'-triphosphate trisodium solution (100 mM) is also applicable to research related to diseases such as leukemia.
For research use only. We do not sell to patients.
- Purity : 98.01%
- CAS No.: 27821-54-1
- Formula: C10H14N2Na3O14P3
- Molecular Weight:548.11
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Storage:
Solution, -20°C, 2 years
Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
Deoxythymidine‑5'-triphosphate trisodium,100 mM Solution,PCR Grade exhibits an average concentration of 1.4 pmol/106 cells in normal bone marrow nucleated cells, while its average concentrations in bone marrow nucleated cells corresponding to acute myeloid leukemia, chronic myeloid leukemia, and myeloproliferative disorders are 5.8 pmol/106 cells, 3.8 pmol/106 cells, and 5.9 pmol/106 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 27821-54-1
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Appearance Liquid
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Molecular Weight 548.11
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Formula C10H14N2Na3O14P3
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Color Colorless to light yellow
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SMILES
O[C@H]([C@H](O1)COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)C[C@@H]1N(C2=O)C=C(C(N2)=O)C
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Synonyms
dTTP trisodium solution (100 mM)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (287 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. European journal of clinical investigation. 1975 Apr;5(2):191-202. [Content Brief]
[2]. Rondan Dueñas JC, et al. Specific requirements for PCR amplification of long mitochondrial A+T-rich DNA. Biotechniques. 1999 Aug;27(2):258-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Deoxythymidine-5'-triphosphate trisodium solution (100 mM)
- 27821-54-1
- dTTP trisodium solution (100 mM)
- DNA/RNA Synthesis
- Nucleoside Antimetabolite/Analog
- Endogenous Metabolite
- chronic granulocytic leukaemia
- acute myeloid leukaemia
- DNA synthesis
- phytohaemagglutinin-stimulated lymphocytes
- leukaemia
- antifolate agents
- nucleated marrow cells
- hydroxyurea
- 5-fluorouracil
- myeloproliferative diseases
- Inhibitor
- inhibitor
- inhibit