Dexamethasone hemisuccinate sodium
Dexamethasone hemisuccinate sodium is a glucocorticoid prodrug and an inhibitor of IL-6 release, and its liposomal formulation is internalized by retinal pigment epithelial cells. Dexamethasone hemisuccinate sodium binds to retinal pigment epithelial cells in a time-dependent manner and exhibits no cytotoxicity toward these cells. Dexamethasone hemisuccinate sodium can be used in research on age-related macular degeneration.
For research use only. We do not sell to patients.
- CAS No.: 3800-84-8
- Formula: C26H32FNaO8
- Molecular Weight:514.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IL-6 |
In Vitro
Dexamethasone hemisuccinate sodium-loaded liposomes (10 mg/mL; 30 days) exhibit a biphasic release profile, with an initial burst followed by sustained release over approximately four weeks, where microfluidic formulations show a higher burst release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ARPE-19 cells
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Concentration:1 and 10 µM dexamethasone hemisuccinate loaded liposomes
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Incubation Time:24 h
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Result:Significantly reduced the pro-inflammatory activity induced by LPS.
At 1 µM dexamethasone concentration, the liposomes obtained by thin-film hydration and microfluidics were 2.3-times and 3-times more efficient than free dexamethasone, respectively.
Empty liposomes produced with both techniques did not present anti-inflammatory activity.
Control plain liposomes did not display pro-inflammatory activity on non-stimulated cells.
Chemical Information
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CAS No. 3800-84-8
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Molecular Weight 514.52
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Formula C26H32FNaO8
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SMILES
C[C@@]12[C@](C[C@H]([C@]2(O)C(COC(CCC(O[Na])=O)=O)=O)C)([H])[C@@]3([H])[C@]([C@H](C1)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dexamethasone hemisuccinate sodium Related Classifications
HY-187658 Related Classifications
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Keywords
- Dexamethasone hemisuccinate
- 3800-84-8
- Interleukin Related
- microfluidic procedure
- age-related macular degeneration
- glucocorticoid prodrug
- IL-6 release inhibitor
- LPS-stimulated ARPE-19 cells
- ARPE-19 cells
- LPS-activated ARPE-19 cells
- thin-film hydration method
- retinal pigment epithelial cells
- liposomal formulations
- Inhibitor
- inhibitor
- inhibit