diABZI STING agonist-1 (tautomerism)
Based on 27 publication(s) in Google Scholar
diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921A). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
For research use only. We do not sell to patients.
- Purity : 99.58%
- CAS No.: 2138498-18-5
- Formula: C42H51N13O7
- Molecular Weight:849.94
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications Citing Use of MedChemExpress (MCE) diABZI STING agonist-1 (tautomerism)
More- Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]
- Genes Dis. 2023 Sep 2;11(6):101074. [Abstract]
- MedComm (2020). 2026 Jun 13;7(6):e70828.
- Adv Sci (Weinh). 2025 Jan;12(2):e2407222. [Abstract]
- Cell Death Differ. 2025 Jun;32(6):1167-1179. [Abstract]
- Cell Death Differ. 2024 Jan;31(1):78-89. [Abstract]
- Cancer Lett. 2024 May 1:589:216836. [Abstract]
- J Exp Med. 2021 Feb 1;218(2):e20200887. [Abstract]
- Chin Herb Med. 2025 Jan 7;17(4):768-778. [Abstract]
- Chin Herb Med. 2024 Apr 30;16(3):422-434. [Abstract]
- Mater Today Bio. 2025 Dec 24.
- Chin Med J (Engl). 2026 Apr 27. [Abstract]
- Cell Chem Biol. 2026 Apr 27:S2451-9456(26)00110-8. [Abstract]
- Cell Rep. 2025 Nov 18;44(12):116581. [Abstract]
- Chin Med. 2024 Aug 15;19(1):107. [Abstract]
- Sci Signal. 2026 Aug 18;19(951):eadx3808.
- J Agric Food Chem. 2026 Mar 25;74(11):9761-9773. [Abstract]
- Int Immunopharmacol. 2026 May 1:176:116468. [Abstract]
- Int Immunopharmacol. 2026 Apr 1:174:116350. [Abstract]
- Cell Oncol (Dordr). 2026 Jan 6;49(1):15. [Abstract]
- Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):13. [Abstract]
- FASEB J. 2025 Apr 15;39(7):e70530. [Abstract]
- Data Brief. 2022 Nov 11:45:108743. [Abstract]
- Res Sq. 2026 Aug 23.
- The Ohio State University. 2026.
- Biomed Pharmacother. 2024 Feb:171:116007. [Abstract]
- University of California San Diego. 2023
-
WB
-
IF
-
WB
Biological Activity
Description
IC50 & Target
EC50: 130 nM (human STNG in PBMCs) [1].
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| H69AR | EC50 |
0.035 μM
Compound: 5; GSK
|
Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay
Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay
|
[PMID: 35108011] |
| H69AR | EC50 |
0.055 μM
Compound: 5; GSK
|
Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay
Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay
|
[PMID: 35108011] |
In Vitro
diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2138498-18-5
-
Appearance Solid
-
Molecular Weight 849.94
-
Formula C42H51N13O7
-
Color White to light yellow
-
SMILES
O=C(N)C1=CC(N/C(N2C/C=C/CN3/C(NC4=C3C(OCCCN5CCOCC5)=CC(C(N)=O)=C4)=N/C(C6=CC(C)=NN6CC)=O)=N\C(C7=CC(C)=NN7CC)=O)=C2C(OC)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (27)
-
Journal Impact Factor
-
Most Recent
-
Cell Res
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity. [Abstract]2022 Dec;32(12):1086-1104. PMID: 36280710
diABZI STING agonist-1 (tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]
Western blot analysis of EVPs isolated from HeLa, HCT116, and B16F10 cells treated with or without 10 µM STING agonist-1 (diABZI), 1 µM cGAMP, or 50 µg/mL DMXAA for 48 h.
diABZI STING agonist-1 (tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]
Immunofluorescence analysis of STING (green) and Flag-RAB22AQ64L (red) in stable Flag-RAB22AQ64L NCI-H1975 cells treated with or without 1 µM STING agonist-1 (diABZI) for 1 h.
diABZI STING agonist-1 (tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]
Western blot analysis of the WCL of the indicated stable 4T1 cells at the indicated time points after treatment with 10 µM STING agonist-1 (diABZI).
-
Genes Dis
Mitophagy deficiency activates stimulator of interferon genes activation and aggravates pathogenetic cardiac remodeling. [Abstract]2023 Sep 2;11(6):101074. PMID: 39281830 -
-
Adv Sci (Weinh)
2025 Jan;12(2):e2407222. PMID: 39558862 -
Cell Death Differ
STING directly interacts with PAR to promote apoptosis upon acute ionizing radiation-mediated DNA damage. [Abstract]2025 Jun;32(6):1167-1179. PMID: 39939798 -
Cell Death Differ
Activating STING/TBK1 suppresses tumor growth via degrading HPV16/18 E7 oncoproteins in cervical cancer. [Abstract]2024 Jan;31(1):78-89. PMID: 38007552 -
Cancer Lett
Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer. [Abstract]2024 May 1:589:216836. PMID: 38556105 -
J Exp Med
Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death. [Abstract]2021 Feb 1;218(2):e20200887. PMID: 33125053 -
Chin Herb Med
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1. [Abstract]2025 Jan 7;17(4):768-778. PMID: 41399788 -
Chin Herb Med
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. [Abstract]2024 Apr 30;16(3):422-434. PMID: 39072201 -
-
Chin Med J (Engl)
Transcranial photobiomodulation mitigates neuroinflammation by suppressing the activation of neurotoxic microglia through inhibition of the cGAS-STING pathway following intracerebral hemorrhage in mice. [Abstract]2026 Apr 27. PMID: 42045151 -
Cell Chem Biol
2026 Apr 27:S2451-9456(26)00110-8. PMID: 42049033 -
Cell Rep
Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses. [Abstract]2025 Nov 18;44(12):116581. PMID: 41259200 -
Chin Med
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding. [Abstract]2024 Aug 15;19(1):107. PMID: 39148120 -
-
J Agric Food Chem
Butachlor-Induced BAZ2B Activation Promotes Cardiomyocyte Senescence through cGAS-STING pathway. [Abstract]2026 Mar 25;74(11):9761-9773. PMID: 41823793 -
Int Immunopharmacol
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment. [Abstract]2026 May 1:176:116468. PMID: 41819671 -
Int Immunopharmacol
Tubular STING drives renal fibrosis via extracellular vesicle-mediated activation of the SMO/GLI-1 pathway. [Abstract]2026 Apr 1:174:116350. PMID: 41679184 -
Cell Oncol (Dordr)
Optimized patient-derived lung cancer organoids recapitulating the immune landscape for precision therapy evaluation. [Abstract]2026 Jan 6;49(1):15. PMID: 41493730 -
Invest Ophthalmol Vis Sci
Involvement of cGAS/STING Signaling in the Pathogenesis of Candida albicans Keratitis: Insights From Genetic and Pharmacological Approaches. [Abstract]2024 Jun 3;65(6):13. PMID: 38848078 -
FASEB J
2025 Apr 15;39(7):e70530. PMID: 40193045 -
Data Brief
2022 Nov 11:45:108743. PMID: 36426057 -
-
-
Biomed Pharmacother
Irisin improves diabetic cardiomyopathy-induced cardiac remodeling by regulating GSDMD-mediated pyroptosis through MITOL/STING signaling. [Abstract]2024 Feb:171:116007. PMID: 38171238 -
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)