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Cat. No.: HY-100977S

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Dimethoxycurcumin-d₆

Name: Dimethoxycurcumin-d6
Brand: MedChemExpress
SKU: HY-100977S
Availability: PreOrder

(Synonyms: DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆)

Dimethoxycurcumin-d₆ (DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆) is the deuterated-labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin (DiMC) is a curcuminoid compound found in Curcuma longa. Dimethoxycurcumin is also an orally active thioredoxin reductase inhibitor (IC₅₀ = 5.4 μM) and androgen receptor antagonist. Dimethoxycurcumin inhibits thioredoxin reductase, leading to oxidized thioredoxin accumulation, ROS production, DNA damage, glutathione depletion, mitochondrial membrane potential decrease, ATP depletion, S phase arrest, and apoptosis. Dimethoxycurcumin inhibits NF-κB, NADPH oxidase subunits, ATP synthase subunits, CDK4, cyclin-D1, FASN, ACC, and the IRS2-PI3K-Akt pathway, while activating AMPK, ERK, and JNK. Dimethoxycurcumin can be used for research on cancer, arsenic-induced hepatotoxicity, and tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 3006902-95-7
Formula: C₂₃H₁₈D₆O₆
Molecular Weight:402.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Dimethoxycurcumin-d₆ Chemical Structure

CAS No.: 3006902-95-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10]^[11]^[12]

thioredoxin reductase

5.4 μM (IC₅₀)

Androgen receptor

NF-κB

CDK4

cyclin-D1

FASN

ACC

IRS2

PI3K

Akt

AMPK

ERK

JNK

All NF-κB Isoforms :

All CDK Isoforms :

All PI3K Isoforms :

All Akt Isoforms :

All AMPK Isoforms :

All ERK Isoforms :

All JNK Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 3006902-95-7
Unlabeled CAS 160096-59-3
Molecular Weight 402.47
Formula C₂₃H₁₈D₆O₆
SMILES

COC1=C(C=CC(/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)OC([2H])([2H])[2H])=O)=O)=C1)OC([2H])([2H])[2H]
Synonyms

DiMC-d₆; CHC 004-d₆; Di-O-methylcurcumin-d₆
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miltonprabu S, et al. Dimethoxycurcumin potentially protects arsenic induced oxidative hepatic injury, inflammation and apoptosis via Nrf2-Keap1 signaling in rats. Biomedicine & Preventive Nutrition. 2014 Oct 1;4(4):561-77.

[2]. Kunwar A, et al. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Archives of toxicology. 2012 Apr;86(4):603-14.

[3]. Hatamipour M, et al. Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties. Journal of cellular physiology. 2018 Dec;233(12):9247-9260.

[4]. Patwardhan RS, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochemical pharmacology. 2011 Sep 15;82(6):642-57. [Content Brief]

[5]. Zoi V, et al. Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers. Biomedicines. 2022 Jan 28;10(2):312.

[6]. Jayakumar S, et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase. Biochemical and biophysical research communications. 2016 Sep 09;478(1):446-454.

[7]. Liu H, et al. Preparation, characterization, in vivo pharmacokinetics, and biodistribution of polymeric micellar dimethoxycurcumin for tumor targeting. International journal of nanomedicine. 2015;10:6395-410.

[8]. Yoon MJ, et al. Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin. Cell death & disease. 2014 Mar 13;5(3):e1112. [Content Brief]

[9]. Nelen J, et al. Targeting Drug Resistance in Cancer: Dimethoxycurcumin as a Functional Antioxidant Targeting ABCC3. Antioxidants (Basel, Switzerland). 2025 May 16;14(5):599.

[10]. Tamvakopoulos C, et al. Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Feb 15;13(4):1269-77.

[11]. Zanetti TA, et al. Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin. Chemico-biological interactions. 2021 Apr 01;338:109410.

[12]. Changtam C, et al. Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. European journal of medicinal chemistry. 2010 Oct;45(10):4446-57.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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Dimethoxycurcumin-d₆

All NF-κB Isoforms

All CDK Isoforms

All PI3K Isoforms

All Akt Isoforms

All AMPK Isoforms

All ERK Isoforms

All JNK Isoforms