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Cat. No.: HY-W540926

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Dimethylglyoxime sodium hydrate

Name: Dimethylglyoxime sodium hydrate
Brand: MedChemExpress
SKU: HY-W540926
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Biacetyl dioxime sodium hydrate)

Dimethylglyoxime sodium hydrate (Biacetyl dioxime sodium hydrate) is an oxime compound. Dimethylglyoxime sodium hydrate selectively coordinates with divalent nickel ions Ni²⁺ to form stable complexes, and can also coordinate with copper ions Cu²⁺, but does not coordinate with iron, selenium or zinc. Dimethylglyoxime sodium hydrate inhibits the aggregation of human β-amyloid 40 peptide in vitro. Dimethylglyoxime sodium hydrate is used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 75006-64-3
Formula: C₄H₂₂N₂Na₂O₁₀
Molecular Weight:304.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

Dimethylglyoxime sodium hydrate Chemical Structure

CAS No.: 75006-64-3

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Aβ/Tau/α-Synuclein AggregationOthers

Aβ/Tau/α-Synuclein Aggregation

Dimethylglyoxime (100-1000 μM; 60 min) sodium hydrate (Biacetyl dioxime sodium hydrate) dose-dependently inhibits aggregation of human recombinant amyloid beta 40 peptide in vitro, with full inhibition achieved at 500 μM and 1000 μM in the absence of supplemented metals or presence of 100 μM Ni²⁺, partial inhibition in the presence of Cu²⁺, and minimal to no inhibition in the presence of Zn²⁺^[1].
Dimethylglyoxime (1 mM; 5 min per injection) sodium hydrate does not directly bind to human recombinant amyloid beta 40 peptide, confirming its inhibitory effect on aggregation is mediated via metal chelation rather than direct peptide interaction^[1].

Others

Dimethylglyoxime sodium hydrate coordinates with nickel and copper ions to form stable complexes in aqueous solution, but does not form detectable complexes with iron, selenium, or zinc ions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dimethylglyoxime (6.1 mg; p.o.; daily; 3 days) sodium hydrate (Biacetyl dioxime sodium hydrate) does not reach detectable levels in the brains of C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6^[1]
Dosage:

6.1 mg
Administration:

p.o.; daily; 3 days
Result:

Was not detected in mouse brain samples via FTICR-MS or NMR analysis.

Related Protocols :

Chemical Information

CAS No. 75006-64-3
Molecular Weight 304.20
Formula C₄H₂₂N₂Na₂O₁₀
SMILES

CC(/C(C)=N/O[Na])=N\O[Na].O.O.O.O.O.O.O.O
Synonyms

Biacetyl dioxime sodium hydrate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Benoit SL, et al. The nickel-chelator dimethylglyoxime inhibits human amyloid beta peptide in vitro aggregation. Scientific reports. 2021 Mar 23;11(1):6622. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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