Allergic Conjunctivitis
Allergic conjunctivitis is an IgE-mediated inflammatory response of the conjunctiva triggered by exposure to airborne allergens such as pollen, dust mites, pet dander, or mold spores. It is part of a systemic atopic reaction and commonly occurs alongside allergic rhinitis, known as allergic rhinoconjunctivitis. Symptoms include itching, redness, swelling, tearing, burning sensations, and mucous discharge in the eyes, often accompanied by systemic signs like sneezing and runny nose. The condition can be seasonal, caused by pollen from trees, grasses, or weeds, or perennial, due to year-round allergens like dust mites and pet dander. Contact allergic conjunctivitis results from direct eye exposure to irritants. Management focuses on allergen avoidance, use of antihistamine or mast cell stabilizer eye drops, and in severe cases, systemic antihistamines or corticosteroids.
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Allergic Conjunctivitis (2)
GD134
Cat. No.: HY-189808
- Formula: C18H24ClF2N5S
- Molecular Weight: 415.93
GD134 is a histamine H1/H4 receptor antagonist that antagonizes H1R and blocks histamine-induced signaling; it acts as an inverse agonist at H4R. GD134 exhibits negligible hERG binding affinity. GD134 reduces ocular hyperemia in a mouse conjunctival allergen challenge model without increasing the squinting score. GD134 can be used for research on allergic conjunctivitis.
GD136
Cat. No.: HY-189807
Synonyms: VUF10775
- Formula: C22H26ClF3N6O2S
- Molecular Weight: 530.99
GD136 (VUF10775) is a histamine H1/H4 receptor antagonist that blocks histamine signaling. The pKi of GD136 for H1 is 7.61 (human), 7.80 (mouse), and 7.44 (rat), and for H4 is 7.93 (human), 7.38 (mouse), 7.28 (rat), and 7.38 (monkey). GD136 alleviates ocular hyperemia. GD136 can be used in research on allergic conjunctivitis.
