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Cat. No.: HY-188169

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Disuprazole

Name: Disuprazole
Brand: MedChemExpress
SKU: HY-188169
Availability: PreOrder

(Synonyms: U-69167)

Disuprazole (U-69167) is an orally active benzimidazole proton pump inhibitor that inhibits gastric H⁺/K⁺-ATPase with an IC₅₀ of 2 × 10^-5 M. Disuprazole reduces gastric acid secretion by inhibiting gastric proton pump activity. Disuprazole can be used in research related to gastric acid secretion and peptic ulcer.

For research use only. We do not sell to patients.

CAS No.: 99499-40-8
Formula: C₁₆H₁₇N₃OS₂
Molecular Weight:331.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Disuprazole Chemical Structure

CAS No.: 99499-40-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[1]

Hog gastric H+/K+-ATPase

20 μM (IC₅₀)

In Vitro

Disuprazole (10 ns) binds to CYP2C9 in an extended conformation 10~15 Å above the heme, and its binding site is stabilized by a water-mediated hydrogen-bonding network and strong hydrophobic interactions^[2].
Disuprazole inhibits hog gastric (H⁺-K⁺)-ATPase activity with an IC₅₀ of 2 × 10⁻⁵ M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Disuprazole (U-69167) (compound 26) (s.c. or p.o.; single administration; 3 h) inhibits gastric H⁺/K⁺-ATPase activity in male Sprague-Dawley rats with ED₅₀ values of 1.0 mg/kg and 15 mg/kg, respectively^[1].
Disuprazole (s.c. or oral administration; single dose) inhibits gastric acid secretion in Carbachol (HY-B1208)-stimulated pylorus-ligated Shay rats, with ED₅₀ values of < 1.0 mg/kg and 2.0-5.0 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 99499-40-8
Molecular Weight 331.46
Formula C₁₆H₁₇N₃OS₂
SMILES

O=S(CC1=NC=CC(SCC)=C1C)C2=NC3=C(N2)C=CC=C3
Synonyms

U-69167
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sih JC, et al. Studies on (H(+)-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors. Journal of medicinal chemistry. 1991 Mar;34(3):1049-62.

[2]. Shi R, et al. Exploration of the binding of proton pump inhibitors to human P450 2C9 based on docking and molecular dynamics simulation. J Mol Model. 2011;17(8):1941-1951.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Disuprazole