DMG-PEG2000-DHLASLWWGTEL

DMG-PEG2000-DHLASLWWGTEL is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. DHLASLWWGTEL peptide: Targeting/functional ligand-the DHLASLWWGTEL peptide (also known as TJ12P1) specifically binds to phosphatidylinositol proteoglycan 3 (GPC3), which is highly expressed on the surface of hepatocellular carcinoma, achieving precise targeting of GPC3-positive cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.