DMG-PEG2000-GALA

DMG-PEG2000-GALA is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. GALA peptide: Targeting/functional ligand-GALA peptide (WEAALAEALAEALAEHLAEALAEALEALAA) is a pH-sensitive peptide that forms an α-helix structure in an acidic environment, leading to liposome leakage and endosome escape, releasing the payload into the cytoplasm.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.