DMG-PEG2000-MG1

DMG-PEG2000-MG1 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. MG1 peptide: Targeting/functional ligand-the MG1 peptide (sequence CHHSSSAR) is an M1 microglia-targeting peptide that can cross the blood-brain barrier (BBB) and precisely recognize M1 microglia, achieving targeted delivery to sites of neuroinflammation in the brain.

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