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Cat. No.: HY-158594

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Docosahexaenoic acid alkyne

Name: Docosahexaenoic acid alkyne
Brand: MedChemExpress
SKU: HY-158594
Price: 590.00 USD
Availability: PreOrder

(Synonyms: DHA-alkyne; FA 22:8)

Docosahexaenoic acid alkyne (DHA-alkyne) is an ω-alkyne derivative of Docosahexaenoic acid (HY-B2167). Docosahexaenoic acid alkyne can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2692622-57-2
Formula: C₂₂H₂₈O₂
Molecular Weight:324.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Docosahexaenoic acid alkyne Chemical Structure

CAS No.: 2692622-57-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Docosahexaenoic acid alkyne (DHA-alkyne) is an ω-alkyne derivative of Docosahexaenoic acid (HY-B2167). Docosahexaenoic acid alkyne can be used in cancer-related research^[1]^[2].

In Vitro

Anti-cancerEndoplasmic Reticulum StressLysosomal Metabolism

Anti-cancer

DHA alkyne (10 μM; 6 h) localizes predominantly to the endoplasmic reticulum, Golgi, late endosomes, and mitochondria in HT29 cells^[1].

Endoplasmic Reticulum Stress

Lysosomal Metabolism

Docosahexaenoic acid alkyne (10 μM; 6 h) localizes to mitochondria, endoplasmic reticulum, and late endosomes, but not to the Golgi, early endosomes or plasma membrane, in PDTO CRC0124^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HT29 colorectal cancer cells
Concentration:

10 μM
Incubation Time:

6 h
Result:

Was actively taken up by cells and was detectable mainly within intracellular compartments.
Accumulated prominently in the ER, Golgi and late endosomal compartments but not in the early endosomal compartments and stressed ER.
Localized considerably on mitochondria.

Chemical Information

CAS No. 2692622-57-2
Molecular Weight 324.46
Formula C₂₂H₂₈O₂
SMILES

C#C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
Synonyms

DHA-alkyne; FA 22:8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. di Blasio L, et al. Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells. Cell death & disease. 2026 Apr 11;17(1):464.

[2]. di Blasio L, et al. Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells. Cell death & disease. 2026 Apr 11;17(1):464.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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