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Cat. No.: HY-P12379

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DOTA-MLN6907

DOTA-MLN6907 is a guanylate cyclase C (GCC) binding agent. DOTA-MLN6907 competitively binds GCC receptors in vitro with an IC₅₀ of approximately 4.6 nM. DOTA-MLN6907, after labeling with Ga-68, can specifically bind to GCC-expressing cancer cells for PET imaging. DOTA-MLN6907 can be used for PET imaging studies of GCC-expressing tumors such as colorectal cancer and for stratified assessment of GCC expression levels.

For research use only. We do not sell to patients.

CAS No.: 1792977-97-9
Formula: C₈₅H₁₂₃N₂₁O₂₈S₇
Molecular Weight:2111.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOTA-MLN6907 Chemical Structure

CAS No.: 1792977-97-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

DOTA-MLN6907 (MLN6907 DSP) (0.5 μM-8.5 μM) inhibits the binding of [¹¹¹In] MLN6907 to GCC in HEK-293 GCC Clone 2 cells via a competitive binding assay, with an IC₅₀ of 4.59 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS No. 1792977-97-9
Molecular Weight 2111.47
Formula C₈₅H₁₂₃N₂₁O₂₈S₇
SMILES

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)[C@@H](CC2=CC=C(NC(NCCCCCC(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(NC3)=O)=O)NC4=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]5CSSC[C@@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(O)=O)=O)NC3=O)=O)=O)=O)=O)CSSC[C@H](C(N[C@@H](CC(N)=O)C(N7[C@@H](CCC7)C(N[C@H]4C)=O)=O)=O)NC5=O)=O)=S)C=C2)CN(CC(O)=O)CC1
Sequence

{(S)-p-SCN-Bn-DOTA}-Ahx-Cys-Cys-Glu-Leu-Cys-Cys-Asn-Pro-Ala-Cys-Ala-Gly-Cys-Tyr (disulfide bridge:Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
Sequence Shortening

{(S)-p-SCN-Bn-DOTA}-Ahx-CCELCCNPACAGCY (disulfide bridge:Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cvet D, et al. Compounds and compositions for imaging gcc-expressing cells: U.S. Patent Application 15/100,883[P]. 2016-10-20.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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