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Cat. No.: HY-160550

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DPM-1003

DPM-1003 is a modulator of protein tyrosine phosphatase 1B (PTP1B) and C-X-C chemokine receptor 4 (CXCR4). DPM-1003 binds to the non-catalytic disordered C-terminal fragment of PTP1B. DPM-1003 inhibits the PI3Kγ-mediated AKT/mTOR signaling pathway downstream of CXCR4. DPM-1003 improves the survival rate of mice in a transfusion-related acute lung injury model, and exerts a lung injury protective effect in preclinical mouse models of acute lung injury and sepsis. DPM-1003 can be used in research related to acute lung injury, acute respiratory distress syndrome, transfusion-related acute lung injury and sepsis.

For research use only. We do not sell to patients.

CAS No.: 3018836-86-4
Formula: C₃₅H₅₇N₃O₃
Molecular Weight:567.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

DPM-1003 Chemical Structure

CAS No.: 3018836-86-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Classifications
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Biological Activity

Description

IC₅₀ & Target

PTP1B

All CXCR Isoforms :

In Vitro

Innate ImmunityCytokines & Chemokines

Innate Immunity

DPM-1003 (4 μM) inhibits PMA-induced AKT phosphorylation in mouse bone marrow-derived neutrophils in vitro^[1].

Innate Immunity

Cytokines & Chemokines

DPM-1003 (2-4 μM) selectively inhibits the PI3Kγ-mediated AKT signaling pathway downstream of CXCR4 in ex vivo models of mouse bone marrow-derived neutrophils and HL-60 promyelocytes, while exerting no significant effect on HeLa cells^[1].
DPM-1003 (4 μM) inhibits the migration of mouse primary neutrophils toward the CXCR4 ligand CXCL12 in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityCytokines & Chemokines

Innate Immunity

DPM-1003 (5-20 mg/kg; i.p.; single dose) dose-dependently improves survival in a murine TRALI model, with 100% survival achieved at a 20 mg/kg single i.p. dose and 80% survival at a 5.0 mg/kg single i.p. dose^[1].

Innate Immunity

Cytokines & Chemokines

DPM-1003 (single dose) induces an aged-neutrophil phenotype in healthy mice, characterized by neutrophilia, reduced granule content, and downregulation of fresh neutrophil surface markers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (TRALI model induced by LPS priming followed by anti-MHC-I antibody injection)^[1]
Dosage:

5.0 mg/kg; 20 mg/kg
Administration:

i.p.; single dose
Result:

Achieved 80% mouse survival at 120 minutes post TRALI induction.
Achieved 100% mouse survival at 120 minutes post TRALI induction.

Related Protocols :

Chemical Information

CAS No. 3018836-86-4
Molecular Weight 567.85
Formula C₃₅H₅₇N₃O₃
SMILES

O[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCC(OC)=O)C)([H])[C@@]4([C@@](CC(CC4)NCCCCNCC5=CN=CC=C5)([H])C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song D, et al. PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils. JCI insight. 2022 Jul 22;7(14):e158199. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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DPM-1003

All CXCR Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DPM-1003 Related Classifications

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