DRP1i27 dihydrochloride
Based on 1 publication(s) in Google Scholar
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury.
For research use only. We do not sell to patients.
- Purity : 98.63%
- Formula: C20H28Cl2N6O
- Molecular Weight:439.38
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DRP1i27 dihydrochloride
More
Biological Activity
Description
In Vitro
DRP1i27 (0-50 μM) dihydrochloride directly binds to and inhibits GTPase activity of human Drp1[1].
DRP1i27 (0-50 μM) dihydrochloride is able to increase cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner[1].
DRP1i27 dihydrochloride has a binding affinity of 286 μM in the SPR assay and a KD value of 190 μM via the MST assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 439.38
-
Formula C20H28Cl2N6O
-
Color Light yellow to brown
-
SMILES
[H]Cl.CC1=C(NC=N1)CN2C[C@@H]3CC[C@@H](N(C3)CC4=CC=C(O4)C5=NNC=C5)C2.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (113.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2759 mL | 11.3797 mL | 22.7593 mL | 56.8984 mL |
| 5 mM | 0.4552 mL | 2.2759 mL | 4.5519 mL | 11.3797 mL | |
| 10 mM | 0.2276 mL | 1.1380 mL | 2.2759 mL | 5.6898 mL | |
| 15 mM | 0.1517 mL | 0.7586 mL | 1.5173 mL | 3.7932 mL | |
| 20 mM | 0.1138 mL | 0.5690 mL | 1.1380 mL | 2.8449 mL | |
| 25 mM | 0.0910 mL | 0.4552 mL | 0.9104 mL | 2.2759 mL | |
| 30 mM | 0.0759 mL | 0.3793 mL | 0.7586 mL | 1.8966 mL | |
| 40 mM | 0.0569 mL | 0.2845 mL | 0.5690 mL | 1.4225 mL | |
| 50 mM | 0.0455 mL | 0.2276 mL | 0.4552 mL | 1.1380 mL | |
| 60 mM | 0.0379 mL | 0.1897 mL | 0.3793 mL | 0.9483 mL | |
| 80 mM | 0.0284 mL | 0.1422 mL | 0.2845 mL | 0.7112 mL | |
| 100 mM | 0.0228 mL | 0.1138 mL | 0.2276 mL | 0.5690 mL |
DRP1i27 dihydrochloride Related Classifications
HY-152086A Related Classifications
Powered by Bioz