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Cat. No.: HY-P11903

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dTBP-3

dTBP-3 is a fully D-configured polypeptide competitive inhibitor that targets TIGIT. dTBP-3 can competitively occupy the binding interface between TIGIT and its ligand PVR, block TIGIT-mediated immunosuppressive signals, and reverse the immune exhaustion of NK cells and CD8⁺ T cells. dTBP-3 possesses anti-proteolytic activity and tumor tissue penetration ability, and can also enhance the tumor penetration capacity and cellular internalization efficiency of nanocarriers. dTBP-3 can be used in studies related to liver cancer, triple-negative breast cancer and non-small cell lung cancer.

For research use only. We do not sell to patients.

Formula: C₇₀H₉₃N₂₁O₁₆
Molecular Weight:1484.62

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Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

dTBP-3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vivo
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Biological Activity

Description

In Vitro

OthersAnti-cancer

Others

dTBP-3 can be completely released from DTBP-3NP-siANRIL within 6 h, while it remains tightly bound in the absence of GSH; in addition, dTBP-3-conjugated nanoparticles are taken up by Hep3B cells in a concentration-dependent manner, which inhibits Hep3B cell proliferation and induces apoptosis^[1].
dTBP-3 conjugated with PLLD forms DTBP-PLLD, which can be liberated from PR-T@PLLD in a pH-dependent pattern and displays elevated release efficiency under acidic lysosomal and tumor microenvironment conditions^[2].
dTBP-3-derived tracer [¹⁸F]TTDP binds to purified human TIGIT protein with a K_D value of 40.14 nM, confirming its high-affinity targeting to human TIGIT^[3].

Anti-cancer

dTBP-3 modification on PR-T@PLLD nanocarriers boosts cellular internalization and strengthens the cytotoxicity of co-loaded PTX and RC, with an IC₅₀ value of 9.57 μg/mL at 48 h; it also facilitates efficient lysosomal escape in anti-PD-1 resistant 4T1 triple-negative breast cancer cells, and yields superior cellular uptake together with reduced lysosomal retention relative to unmodified nanocarriers^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancerInnate ImmunityAdaptive ImmunityApoptosisCytokines & ChemokinesOthers

Anti-cancer

Innate Immunity

Adaptive Immunity

Apoptosis

dTBP-3 inhibits hepatocellular carcinoma by blocking the TIGIT/PVR pathway to enhance tumor immunity, increase the proportions of NK cells and T cells, slow tumor growth, and prolong the survival of tumor-bearing mice^[1].

Anti-cancer

Adaptive Immunity

Innate Immunity

Cytokines & Chemokines

Apoptosis

dTBP-3 (40 mg/kg, administered via tail vein base injection once every 3 days for a total of 5 doses) can enhance the in vivo anti-tumor effect against anti-PD-1-resistant triple-negative breast cancer via the PR-T@PLLD nanoplatform, strengthen the activity of CD8⁺ cytotoxic T cells, remodel the tumor immune microenvironment, and promote the secretion of pro-inflammatory cytokines; it can also induce the formation of immune memory in the body and effectively inhibit lung metastasis of triple-negative breast cancer^[2].

Others

dTBP-3 can be used to synthesize the intravenous tracer [¹⁸F]TTDP. This probe specifically targets TIGIT-positive tumor-infiltrating lymphocytes in mice and humans, shows significantly higher tumor uptake than all control groups, can quantitatively reflect the intratumoral TIGIT expression level, predict the intervention effect of combined immunotherapy, and shares the same urinary metabolic clearance pathway in rhesus monkeys as in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 1484.62
Formula C₇₀H₉₃N₂₁O₁₆
Sequence

Gly-Gly-D-{Tyr-Thr-Phe-His-Trp-His-Arg-Leu-Asn-Pro}
Sequence Shortening

GGytfhwhrlnp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang T, et al. TIGIT/PVR and LncRNA ANRIL dual-targetable PAMAM polymeric nanoparticles efficiently inhibited the hepatoma carcinoma by combination of immunotherapy and gene therapy. Journal of drug targeting. 2021 Aug;29(7):783-791.

[2]. Wang J, et al. Tumor targeting dendritic nanocarrier with immunogenic cell death inducing and TIGIT blockade for synergistic chemo-immunotherapy against TNBC. Journal of nanobiotechnology. 2025 Dec 07;23(1):759.

[3]. Wang J, et al. Development and characterisation of [F]TTDP, a novel T cell immunoglobulin and ITIM domain tracer, in humanised mice and non-human primates. European journal of nuclear medicine and molecular imaging. 2025 Jan;52(2):416-426.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
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dTBP-3

Biological Activity

Description

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

dTBP-3 Related Classifications

HY-P11903 Related Classifications

Bioz

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