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Cat. No.: HY-111290

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(E)-MDL72274 hydrochloride

(E)-MDL72274 hydrochloride is a semicarbazide-sensitive amine oxidase (SSAO) inhibitor with an IC₅₀ value of 0.74-1.42 μM. (E)-MDL72274 hydrochloride inhibits allylamine-induced excessive contraction of isolated coronary artery bypass graft vessels. (E)-MDL72274 hydrochloride can be used in studies related to vasospasm.

For research use only. We do not sell to patients.

CAS No.: 85278-24-6
Formula: C₉H₁₁Cl₂N
Molecular Weight:204.10

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-MDL72274 hydrochloride Chemical Structure

CAS No.: 85278-24-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
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Biological Activity

Description

In Vitro

Local Vascular RegulationOthers

Local Vascular Regulation

(E)-MDL72274 (0.1 mM; 20 min) hydrochloride completely blocks Allylamine-induced hypercontraction and associated vascular dysfunction in isolated human internal mammary artery rings by inhibiting SSAO activity^[1].

Others

(E)-MDL72274 (1 nM-0.1 mM; 30 min) hydrochloride potently inhibits SSAO activity in homogenized human internal mammary artery, radial artery, and saphenous vein with IC₅₀ values ranging from 0.74-1.42 μM, and completely blocks SSAO activity at 0.1 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 85278-24-6
Molecular Weight 204.10
Formula C₉H₁₁Cl₂N
SMILES

Cl/C=C(C1=CC=CC=C1)/CN.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Conklin DJ, et al. Acrolein generation stimulates hypercontraction in isolated human blood vessels. Toxicology and applied pharmacology. 2006 Dec 15;217(3):277-88.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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