E3 ligase Ligand PG
Based on 1 Customer Validation
E3 ligase Ligand PG is an E3 ligase CRBN ligand with an IC50 of 2.191 μM. E3 ligase Ligand PG can be connected to BMS-202 (HY-19745) via a linker to form the PROTAC PROTAC PD-L1 degrader-1 (HY-163757).
For research use only. We do not sell to patients.
- Purity : 99.94%
- CAS No.: 14149-34-9
- Formula: C11H11NO2
- Molecular Weight:189.21
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Cereblon 2.191 μM (IC50) |
In Vitro
Chemical Information
-
CAS No. 14149-34-9
-
Appearance Solid
-
Molecular Weight 189.21
-
Formula C11H11NO2
-
Color White to off-white
-
SMILES
O=C1CCC(C(N1)=O)C2=CC=CC=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 116.67 mg/mL (616.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2851 mL | 26.4257 mL | 52.8513 mL | 132.1283 mL |
| 5 mM | 1.0570 mL | 5.2851 mL | 10.5703 mL | 26.4257 mL | |
| 10 mM | 0.5285 mL | 2.6426 mL | 5.2851 mL | 13.2128 mL | |
| 15 mM | 0.3523 mL | 1.7617 mL | 3.5234 mL | 8.8086 mL | |
| 20 mM | 0.2643 mL | 1.3213 mL | 2.6426 mL | 6.6064 mL | |
| 25 mM | 0.2114 mL | 1.0570 mL | 2.1141 mL | 5.2851 mL | |
| 30 mM | 0.1762 mL | 0.8809 mL | 1.7617 mL | 4.4043 mL | |
| 40 mM | 0.1321 mL | 0.6606 mL | 1.3213 mL | 3.3032 mL | |
| 50 mM | 0.1057 mL | 0.5285 mL | 1.0570 mL | 2.6426 mL | |
| 60 mM | 0.0881 mL | 0.4404 mL | 0.8809 mL | 2.2021 mL | |
| 80 mM | 0.0661 mL | 0.3303 mL | 0.6606 mL | 1.6516 mL | |
| 100 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL | 1.3213 mL |
E3 ligase Ligand PG Related Classifications
HY-150839 Related Classifications
Powered by Bioz