EA-Ri-153
EA-Ri-153 is a selective D3R agonist. EA-Ri-153 has a Ki = 2.8 nM and pEC50 = 8.9 for D3R, and a Ki = 1.2 μM for D2R, with a D3/D2 selectivity ratio of 435-fold. EA-Ri-153 has a Ki = 2.5 μM for 5-HT1AR and a Ki = 22.8 μM for 5-HT2AR. EA-Ri-153 can be used for research on diseases related to the dopamine D3 receptor subtype.
For research use only. We do not sell to patients.
- Formula: C22H36FN3O4S
- Molecular Weight:457.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
D3 Receptor 2.8 nM (Ki) |
D3 Receptor 8.9 (pEC50) |
D2 Receptor 1.2 nM (Ki) |
In Vitro
EA-Ri-153 is a potent agonist of WT D3R in HEK293 cells, with a pEC50 of 8.9 and an Emax of 107% in the GαoA BRET GPA assay[1].
EA-Ri-153 has a Ki = 2.5 μM for 5‑HT1AR and a Ki = 22.8 μM for 5‑HT2AR[1].
EA-Ri-153 shows a logPe of -4.53 in BBB-PAMPA, with a predicted logBB of 0.76[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 457.60
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Formula C22H36FN3O4S
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SMILES
O=S(CCOC)(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(OC)=C3F)CC2)CC1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EA-Ri-153 Related Classifications
HY-189719 Related Classifications
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