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Cat. No.: HY-189877

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EGFR-IN-221

EGFR-IN-221 is a EGFR inhibitor. EGFR-IN-221 inhibits EGFR tyrosine kinase activity with an IC₅₀ of 0.26 μM. EGFR-IN-221 exerts antiproliferative and cytotoxic effects on lung cancer cell lines. EGFR-IN-221 can be used in lung cancer-related research.

For research use only. We do not sell to patients.

Formula: C₁₉H₁₁Cl₂FN₆O₃S
Molecular Weight:493.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-221 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

EGFR

0.26 μM (IC₅₀)

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC50	3.17 μM	Cytotoxicity against human A-549 lung adenocarcinoma cells. Cytotoxicity against human A-549 lung adenocarcinoma cells.	42070755
NCI-H460	IC50	6.51 μM	Cytotoxicity against human NCI-H460 lung carcinoma cells. Cytotoxicity against human NCI-H460 lung carcinoma cells.	42070755
HEK293	IC50	17.89 μM	Cytotoxicity against normal human HEK-293 embryonic kidney cells. Cytotoxicity against normal human HEK-293 embryonic kidney cells.	42070755

In Vitro

Anti-cancerOthers

Anti-cancer

EGFR-IN-221 (compound 8f) (3.125-100 μM) exhibits antiproliferative activity against A-549 and NCI-H460 lung cancer cells with IC₅₀ values of 3.17 and 6.51 μM, respectively, and shows low cytotoxicity toward normal HEK-293 cells^[1].

Others

EGFR-IN-221 inhibits EGFR tyrosine kinase in cell-free assays with an IC₅₀ of 0.26 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 493.30
Formula C₁₉H₁₁Cl₂FN₆O₃S
SMILES

O=S1(CC(C2=CC=C(C=C2)F)=NN3C(CC4=NOC(C5=CC(Cl)=CC(Cl)=C5)=N4)=NN=C31)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Raju J, et al. Design and synthesis of [1,2,4]triazolo[3,4-b]thiadiazine-1,2,4-oxadiazoles as EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2026 Sep;138:130678.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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