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Cat. No.: HY-175162

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EGFR ligand-20

EGFR ligand-20 is a EGFR-binding ligand that serves as a target protein ligand for ZSH-2117 (HY-174415) and is used in studies related to PROTAC synthesis.

For research use only. We do not sell to patients.

Formula: C₁₂H₁₃ClN₃OP
Molecular Weight:281.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR ligand-20 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

EGFR ligand-20 is a EGFR-binding ligand that serves as a target protein ligand for ZSH-2117 (HY-174415) and is used in studies related to PROTAC synthesis^[1].

All EGFR Isoforms :

In Vitro

EGFR ligand-20 acts as a target protein ligand for ZSH-2117 (HY-174415), a covalent and selective EGFR PROTAC degrader with a DC₅₀ of 45 nM. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFRL858R/T790M/C797S xenograft mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 281.68
Formula C₁₂H₁₃ClN₃OP
SMILES

O=P(C1=CC=CC=C1NC2=NC=NC=C2Cl)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. He X, et al. Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders. Journal of the American Chemical Society. 2025 Jun 25;147(25):21512-21525. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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