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Cat. No.: HY-P12216

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Enlicitide northern fragment 4

Enlicitide northern fragment 4 is a key intermediate obtained via the retrosynthetic disconnection of Enlicitide decanoate (HY-W1126955). Enlicitide northern fragment 4 participates in the protecting-group-free biocatalytic convergent assembly of Enlicitide decanoate, an oral macrocyclic peptide PCSK9 inhibitor. Enlicitide northern fragment 4 can be used for the synthesis of Enlicitide decanoate, thereby supporting research related to hypercholesterolemia.

For research use only. We do not sell to patients.

CAS No.: 3115127-25-5
Formula: C₄₅H₆₀FN₇O₁₆
Molecular Weight:973.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Enlicitide northern fragment 4 Chemical Structure

CAS No.: 3115127-25-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

The northern fragment 4 of Enlicitide (50 mM; 32 h) undergoes a selective intermolecular transacylation reaction with Eastern fragment 3 catalyzed by engineered BITEEng, producing the coupled amino alcohol product with 89% LCAP and very low levels of by-products^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3115127-25-5
Molecular Weight 973.99
Formula C₄₅H₆₀FN₇O₁₆
SMILES

OC(C(O)=O)=O.NCCCCCCN1C(C(C(C[C@H]2C([N@]3[C@@H]([C@](OCC(NCC4=CC=CC(C[C@@H](C(N2)=O)N)=C4)=O)([H])CC3)C(N[C@@H]([C@H](O)C)C(OC(C)C)=O)=O)=O)=C1)=C5)=CC=C5F.OC(C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Klapars A, et al. Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide. Science (New York, N.Y.). 2026 May 07;392(6798):643-647. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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