Enniatin B-13C33
Enniatin B-13C33 is the 13C-labeled Enniatin B (HY-N3806). Enniatin B is a Fusarium mycotoxin that acts as an ionophore to form cation-selective membrane channels, disrupt ion homeostasis and mitochondrial function, inhibit cell proliferation, and induce apoptosis, while modulating ERK, p38 MAPK, and STAT3 signaling pathways. Enniatin B is used in research on atherosclerosis, hypercholesterolemia, cervical cancer, and colon adenocarcinoma.
For research use only. We do not sell to patients.
- Formula: 13C33H57N3O9
- Molecular Weight:672.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[11]|
ERK |
p38 MAPK |
STAT3 |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 917-13-5
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Molecular Weight 672.58
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Formula 13C33H57N3O9
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SMILES
[13CH3][13CH]([13C@](O1)([H])[13C](N([13C@H]([13C](O[13C@@H]([13C](N([13C@]([13CH]([13CH3])[13CH3])([H])[13C](O[13C@H]([13CH]([13CH3])[13CH3])[13C](N([13CH3])[13C@@H]([13CH]([13CH3])[13CH3])[13C]1=O)=O)=O)[13CH3])=O)[13CH]([13CH3])[13CH3])=O)[13CH]([13CH3])[13CH3])[13CH3])=O)[13CH3]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Prosperini A, et al. A Review of the Mycotoxin Enniatin B. Frontiers in public health. 2017;5:304.
[3]. Kalayou S, et al. An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays. Toxicology letters. 2015 Mar 04;233(2):84-94. [Content Brief]
[4]. Rodríguez-Carrasco Y, et al. Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin. Toxicology letters. 2016 Apr 15;247:35-44. [Content Brief]
[5]. Ivanova L, et al. Lysosomes as a possible target of enniatin B-induced toxicity in Caco-2 cells. Chemical research in toxicology. 2012 Aug 20;25(8):1662-74. [Content Brief]
[8]. Behm C, et al. The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro. Molecular nutrition & food research. 2009 Apr;53(4):423-30. [Content Brief]
[9]. Ficheux AS, et al. Effects of beauvericin, enniatin b and moniliformin on human dendritic cells and macrophages: an in vitro study. Toxicon : official journal of the International Society on Toxinology. 2013 Sep;71:1-10. [Content Brief]
[10]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PloS one. 2018;13(5):e0197406. [Content Brief]
[11]. Dornetshuber-Fleiss R, et al. The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo. Biochemical pharmacology. 2015 Feb 01;93(3):318-331. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enniatin B-13C33 Related Classifications
HY-N3806S Related Classifications
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