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Cat. No.: HY-116865S

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Equilenin-4,16,16-d₃

Name: Equilenin-4,16,16-d3
Brand: MedChemExpress
SKU: HY-116865S
Price: 4646.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Equilenin-4,16,16-d₃ is the d₃-labeled Equilenin (HY-116865). Equilenin is a B-ring unsaturated estrogen discovered in pregnant mare urine and is one of the major components of Premarin, a drug commonly used for estrogen replacement therapy. Equilenin binds to estrogen receptors in the body and exerts effects similar to endogenous estrogens. Equilenin weakly binds to and activates the aryl hydrocarbon receptor (AhR) to induce CYP1A1 expression. Equilenin exhibits high affinity for sex hormone-binding globulin (SHBG/SBP) and is metabolized by CYP1A1/1B1 to 4-hydroxy and 17β-dihydro derivatives. Equilenin is used in breast cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 56588-54-6
Formula: C₁₈H₁₅D₃O₂
Molecular Weight:269.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Equilenin-4,16,16-d₃ Chemical Structure

CAS No.: 56588-54-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All Endogenous Metabolite Isoforms :

All Cytochrome P450 Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 56588-54-6
Unlabeled CAS 517-09-9
Molecular Weight 269.35
Formula C₁₈H₁₅D₃O₂
SMILES

C[C@]1([C@](CC2([2H])[2H])([H])C3=CC=C4C([2H])=C(O)C=CC4=C3CC1)C2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jinno A, et al. Induction of cytochrome P450-1A by the equine estrogen equilenin, a new endogenous aryl hydrocarbon receptor ligand. The Journal of steroid biochemistry and molecular biology. 2006 Jan;98(1):48-55.

[2]. Ross JB, et al. Equilenin: a specific fluorescent probe for steroid-protein interactions in sex steroid-binding protein. FEBS letters. 1982 Nov 29;149(2):240-4.

[3]. Spink DC, et al. Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chemical research in toxicology. 2001 May;14(5):572-81. [Content Brief]

[4]. Uchida M, et al. Developmental toxicity and transcriptome analysis of equine estrogens in developing medaka (Oryzias latipes) using nanosecond pulsed electric field incorporation. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023 Apr;266:109547.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Equilenin-4,16,16-d3

All Endogenous Metabolite Isoforms

All Cytochrome P450 Isoforms

Biological Activity

Description

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Equilenin-4,16,16-d3 Related Classifications

HY-116865S Related Classifications

Bioz

Keywords

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